Not Only Melatonin but also Caffeic Acid Phenethyl Ester Protects Kidneys against Aging-related Oxidative Damage in Sprague Dawley Rats

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorIraz, Mustafa
dc.contributor.authorAtes, Burhan
dc.contributor.authorGul, Mehmet
dc.date.accessioned2024-08-04T20:36:03Z
dc.date.available2024-08-04T20:36:03Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMicroscopic features and antioxidant status of kidneys of young, old, and caffeic acid phenethyl ester (CAPE) and melatonin administered old Sprague Dawley rats were evaluated. Aging-related tubular and glomerular changes were evident. The most prominent tubular alterations were massive vacuole formation, mitochondrial degeneration, and lysosome accumulation. Mean tissue malondialdehyde (MDA) level was increased, mean tissue superoxide dismutase (SOD), catalase (CAT) (p<.001), and glutathione peroxidase (GPx) activities (p<.05), and total glutathione (GSH) level were decreased in old animals. Melatonin significantly reduced tissue MDA levels (p<.005), but increased tissue SOD (p<.001), CAT, and GPx activities (p<.05), and GSH levels (p<.005) in old animals. CAPE also significantly reduced tissue MDA levels (p<.005), but increased tissue SOD (p<.05), CAT (p<.005), GPx activities, and GSH levels (p<.001) in old rats. Mean tissue MDA levels of melatonin and CAPE-administered rats were even lower than those of young rats (p<.05). In conclusion, tubular and glomerular structures and tissue antioxidant enzyme activities were very well preserved in CAPE and melatonin-administered rats.en_US
dc.identifier.doi10.3109/01913123.2012.679351
dc.identifier.endpage251en_US
dc.identifier.issn0191-3123
dc.identifier.issue4en_US
dc.identifier.pmid22849526en_US
dc.identifier.scopus2-s2.0-84864534565en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage244en_US
dc.identifier.urihttps://doi.org/10.3109/01913123.2012.679351
dc.identifier.urihttps://hdl.handle.net/11616/95762
dc.identifier.volume36en_US
dc.identifier.wosWOS:000306968500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgingen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectkidneyen_US
dc.subjectmelatoninen_US
dc.subjectoxidative stressen_US
dc.titleNot Only Melatonin but also Caffeic Acid Phenethyl Ester Protects Kidneys against Aging-related Oxidative Damage in Sprague Dawley Ratsen_US
dc.typeArticleen_US

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