Electron Microscopic and Histological Evaluation of the Levator Muscle in Patients with Congenital Blepharoptosis

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dc.authoridSeker, Ugur/0000-0002-1693-6378
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidSeker, Ugur/A-7403-2014
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorSoker, Sevda
dc.contributor.authorCakmak, Sevin
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorDeveci, Engin
dc.contributor.authorGul, Mehmet
dc.contributor.authorSoker, Murat
dc.contributor.authorAkkus, Murat
dc.date.accessioned2024-08-04T20:41:50Z
dc.date.available2024-08-04T20:41:50Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: To examine the levator muscle in patients with congenital blepharoptosis and to investigate the relationship between those findings and age, gender, and degree of blepharoptosis. STUDY DESIGN: The levator muscles of 13 congenital ptosis patients who had undergone levator muscle resection were examined by light and electron microscopy. During the preoperative period the ptosis amount, levator function, tear function, Bell's phenomenon, and jaw-wink phenomenon were evaluated. RESULTS: There were 9 (69.2%) male and 4 (30.8%) female cases, with an average age of 10.61 +/- 4.77 years (range, 4-19). The quality and quantity of the levator muscle fibrils were assessed by histological examination. There was no relationship detected between histological features of levator palpebralis superior muscle and patients' age and gender (p < 0.05). Patients with a weak levator palpebralis superior muscle had fatty degeneration histologically. Higher levator palpebralis superior muscle function correlated with decreased fatty degeneration and increased skeletal muscle fibrils, but these findings were not statistically significant. There was a reduction in the diameter of muscle fibers and nucleus deformation when muscle function was examined in patients under low-magnification electron microscope. There were lipid droplets of various sizes in some sections, and the mitochondria were seen in mitochondrial crystalline structure depending on cytopathies. In some sections of this group there was large mitochondria and edema formation due to an increase in the mitochondrial matrix. CONCLUSION: More ultrastructural studies in larger populations are needed to support the relationship between structure and function of levator palpebralis superior muscle in patients with congenital blepharoptosis.en_US
dc.identifier.endpage198en_US
dc.identifier.issn0884-6812
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84975529321en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://hdl.handle.net/11616/97382
dc.identifier.volume38en_US
dc.identifier.wosWOS:000399656100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbirth defects, blepharoptosisen_US
dc.subjectcongenital blepharoptosisen_US
dc.subjectcongenital defectsen_US
dc.subjectdrooping eyelid eyeen_US
dc.subjectlevator muscle, electron microscopyen_US
dc.subjectmicroscopy, polarized lighten_US
dc.subjectoculomotor-levator synkinesisen_US
dc.subjectocular motility disordersen_US
dc.subjectptosis, eyeliden_US
dc.titleElectron Microscopic and Histological Evaluation of the Levator Muscle in Patients with Congenital Blepharoptosisen_US
dc.typeArticleen_US

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