Intensive chemotherapy perturbs heart rate variability in children with cancer

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dc.authorwosidYILDIZ, SEDAT/AAB-6354-2021
dc.contributor.authorCakan, Pinar
dc.contributor.authorYildiz, Sedat
dc.contributor.authorAkyay, Arzu
dc.contributor.authorOncul, Yurday
dc.date.accessioned2024-08-04T20:50:57Z
dc.date.available2024-08-04T20:50:57Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: In children, cancer chemotherapy may impair the functioning of the cardiac autonomic nervous system. Moreover, it is not known whether there are any differences between intensive and maintenance phases of chemotherapy. Therefore, the aim of the current study was to assess autonomic nervous system activity using heart rate variability, in children receiving intensive or maintenance cancer chemotherapy. Methods: For that purpose, children who were healthy (healthy control, n = 30), receiving intensive chemotherapy (chemotherapy, n = 30), and receiving maintenance chemotherapy (maintenance, n = 25) were included in the study. Autonomic nervous system activity was measured by means of heart rate variability. Electrocardiogram recordings were used to calculate time- and frequency-domain heart rate variability parameters. Results: Time-domain parameters such as standard deviation of NN intervals and frequencydomain parameters such as total power were lower during the intensive chemotherapy but not during maintenance phase (standard deviation of NN intervals: 50 +/- 5, 33 +/- 3, and 48 +/- 3 ms, and total power: 2613 +/- 504, 1379 +/- 296 and 2295 +/- 264 ms2, respectively for healthy control, chemotherapy and maintenance groups, P<0.001 for both standard deviation of NN intervals and total Discussion: The present results indicate that intensive chemotherapy perturbs the function of heart rate variability in children, with recovery during the maintenance phase. This suggests that intensive chemotherapy is likely to affect the autonomic nervous system but this effect does not appear to be permanent. (c) 2021 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.neucli.2021.11.001
dc.identifier.endpage80en_US
dc.identifier.issn0987-7053
dc.identifier.issn1769-7131
dc.identifier.issue1en_US
dc.identifier.pmid34973888en_US
dc.identifier.scopus2-s2.0-85121971511en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.1016/j.neucli.2021.11.001
dc.identifier.urihttps://hdl.handle.net/11616/100386
dc.identifier.volume52en_US
dc.identifier.wosWOS:000760321900007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofNeurophysiologie Clinique-Clinical Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutonomic nervousen_US
dc.subjectChemotherapyen_US
dc.subjectHeart rate variabilityen_US
dc.subjectIntensiveen_US
dc.subjectsystemen_US
dc.subjectCanceren_US
dc.titleIntensive chemotherapy perturbs heart rate variability in children with canceren_US
dc.typeArticleen_US

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