Melatonin preserves ovarian tissues of rats exposed to chronic TCDD: An electron microscopic approach to effects of TCDD on ovarian cells

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dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidGül, Semir/ABI-8244-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorGul, Semir
dc.contributor.authorGul, Mehmet
dc.contributor.authorYigitcan, Birgul
dc.date.accessioned2024-08-04T20:44:21Z
dc.date.available2024-08-04T20:44:21Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstract2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic agent and has disruptive effects on reproductive tissues in females. TCDD disrupts the hormonal regulation of the body and decreases the production of melatonin. In this study, we investigated the protective effects of melatonin supplements against the toxic effects of TCDD on ovaries of female rats. TCDD caused a significant decrease in the average number of corpora lutea and follicles per tissue section (2.1 +/- 0.7; 2.3 +/- 0.8, respectively), whereas these numbers were maintained in the melatonin supplemented group (5.0 +/- 0.8; 5.1 +/- 0.8, respectively) and were similar to the control group (5.3 +/- 1.0; 5.9 +/- 0.9, respectively). Electron microscopic analysis showed that the disruption of ultrastructure components such as cell membrane and organelles due to TCDD exposure was inhibited by melatonin supplements. This study suggested that melatonin has a protective and a possible ameliorative effect over histopathological damage of rat ovaries exposed to TCDD.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Committee (BAP)en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Inonu University Scientific Research Projects Committee (BAP).en_US
dc.identifier.doi10.1177/0748233717754174
dc.identifier.endpage236en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue4en_US
dc.identifier.pmid29529941en_US
dc.identifier.scopus2-s2.0-85043688689en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://doi.org/10.1177/0748233717754174
dc.identifier.urihttps://hdl.handle.net/11616/98194
dc.identifier.volume34en_US
dc.identifier.wosWOS:000429970500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2,3,7, 8-Tetrachlorodibenzo-p-dioxinen_US
dc.subjectovaryen_US
dc.subjectmelatoninen_US
dc.subjectraten_US
dc.subjectdioxinsen_US
dc.titleMelatonin preserves ovarian tissues of rats exposed to chronic TCDD: An electron microscopic approach to effects of TCDD on ovarian cellsen_US
dc.typeArticleen_US

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