Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome

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dc.authoridElmas, Ahmet Taner/0000-0002-9749-6115
dc.authorwosidELMAS, Ahmet Taner/W-4101-2017
dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.authorwosidElmas, Ahmet Taner/ABI-1338-2020
dc.contributor.authorElmas, Ahmet Taner
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorElmas, Ozlem Nalbantoglu
dc.date.accessioned2024-08-04T20:37:32Z
dc.date.available2024-08-04T20:37:32Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to compare serum cystatin C levels (sCysC) in preterm neonates with respiratory distress syndrome (RDS) with a control group and to investigate whether it could be used as a predictor for acute kidney injury (AKI). sCysC was measured in 62 neonates with RDS (n = 28) and control neonates without RDS (n = 34), whose gestational ages (GA) were between 27 and 29 weeks (subgroup 1) and 30-32 weeks (subgroup 2). AKI was defined as oliguria and/or increase of serum creatinine. Blood samples were obtained on postnatal days (PND) 3 and 30. sCysC levels were determined by particle-enhanced nephelometric immunoassay. There were six neonates with AKI (RDS-AKI subgroup) and 22 neonates without AKI (RDS-no AKI subgroup) during the first 7 days. Although sCysC levels were lower in neonates with RDS than controls on PND3 in both GA subgroups, the differences were not significant. However, in neonates with RDS and AKI, sCysC levels were significantly higher than neonates with RDS but no AKI and neonates in the control group on PND3. sCysC level was found to have a statistically significant association with AKI development in preterm neonates with RDS. sCysC is an independent predictor of AKI in preterm neonates with RDS.en_US
dc.identifier.doi10.1007/s00467-012-2331-5
dc.identifier.endpage484en_US
dc.identifier.issn0931-041X
dc.identifier.issue3en_US
dc.identifier.pmid23070277en_US
dc.identifier.scopus2-s2.0-84876291828en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage477en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-012-2331-5
dc.identifier.urihttps://hdl.handle.net/11616/96009
dc.identifier.volume28en_US
dc.identifier.wosWOS:000314038000015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPretermen_US
dc.subjectNeonatesen_US
dc.subjectRespiratory distress syndromeen_US
dc.subjectAcute kidney injuryen_US
dc.subjectSerum cystatin Cen_US
dc.titleSerum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndromeen_US
dc.typeArticleen_US

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