Investigation of human papillomavirus and Epstein-Barr virus DNAs in pterygium tissue

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dc.authoridEmre, Sinan/0000-0002-9788-3895
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridturkcuoglu, peykan/0000-0002-9750-6213
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidEmre, Sinan/T-5643-2019
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidturkcuoglu, peykan/GQB-2596-2022
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorOtlu, Baris
dc.contributor.authorEmre, Sinan
dc.contributor.authorTurkcuoglu, Peykan
dc.contributor.authorDoganay, Selim
dc.contributor.authorDurmaz, Riza
dc.date.accessioned2024-08-04T20:31:11Z
dc.date.available2024-08-04T20:31:11Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE. Recent studies postulated the presence of a probable relationship between pterygium and neoplasia. This study aimed to investigate the role of two oncogenic viruses, human papillomavirus (HPV) and Epstein-Barr virus (EBV), in the development of conjunctival pterygia. METHODS. Polymerase chain reaction was used to identify the presence of HPV and EBV in 30 primary and 10 recurrent pterygia samples. Twenty conjunctival samples obtained from patients undergoing cataract surgeries were used as the control group. Patient groups had similar sex, race, and age distribution to eliminate bias. For exploration of HPV in groups, two different PCR methods (in-house PCR with two different primer sets and one real-time PCR method) were studied. The presence of EBV was shown by real-time PCR method. RESULTS. HPV was identified in none of the pterygia and control group patients. However, EBV was detected in 3 out of 30 (10%) primary pterygia patients and in none of the recurrent pterygia and control patients. CONCLUSIONS. Up to now, HPV has been blamed as the major viral pathogen in the etiopathogenesis of pterygium. The current results suggest that EBV may also be involved in the pathogenesis of pterygium, but further larger studies with larger cohorts are required to confirm this hypothesis. (Eur J Ophthalmol 2009; 19: 175-9)en_US
dc.description.sponsorshipMolecular and Clinical Microbiology Society, Malatya, Turkeyen_US
dc.description.sponsorshipPartially supported by Molecular and Clinical Microbiology Society, Malatya, Turkey.en_US
dc.identifier.doi10.1177/112067210901900201
dc.identifier.endpage179en_US
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue2en_US
dc.identifier.pmid19253231en_US
dc.identifier.scopus2-s2.0-65249143448en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://doi.org/10.1177/112067210901900201
dc.identifier.urihttps://hdl.handle.net/11616/94789
dc.identifier.volume19en_US
dc.identifier.wosWOS:000265598800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofEuropean Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEBVen_US
dc.subjectHPVen_US
dc.subjectPterygiumen_US
dc.subjectReal time PCRen_US
dc.titleInvestigation of human papillomavirus and Epstein-Barr virus DNAs in pterygium tissueen_US
dc.typeArticleen_US

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