Impairment of Peripheral Nerve Healing After Nerve Repair in Rats Chronically Exposed To Alcohol

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dc.authoridErtem, Kadir/0000-0002-8892-494X
dc.authoridYologlu, Saim/0000-0002-9619-3462;
dc.authorwosidErtem, Kadir/ABG-9780-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidceylan, mehmet fethi/ABF-1126-2020
dc.contributor.authorErtem, Kadir
dc.contributor.authorCeylan, Fethi
dc.contributor.authorZorludemir, Suzan
dc.contributor.authorKarakoc, Yunus
dc.contributor.authorYologlu, Saim
dc.date.accessioned2024-08-04T20:31:18Z
dc.date.available2024-08-04T20:31:18Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims. The aim of this study was to determine the effect of chronic alcoholism on the healing of repaired peripheral nerve and muscle. Methods. Group 1 rats (n = 9) were fed with an alcohol-free modified liquid diet (MLD) throughout the experiment and received no nerve transection or repair. Group 2 rats (n = 9) were fed the same isocaloric MLD and underwent nerve transection and repair. Group 3 (n 7) consisted of alcoholic rats without nerve transection and repair and Group 4 (it 8) consisted of alcoholic rats with nerve transection and repair. To assess the effects of chronic alcoholism on nerve healing, surgical procedures were applied to rats in Groups 2 and 4. After 2 months, posterior tibial nerve and gastrocnemius muscle samples were taken for histological analysis. Results. Group 2 rats displayed a group of atrophic fibers, whereas Group 3 rats showed myophagocytosis and endomysial mononuclear infiltration and type 2 fiber atrophy. Group 4 rats displayed a large section of atrophic fibres. Axonal loss, prominent regenerative clusters and endoneural fibrosis Occurred in Group 2 rats. Axonal and myelin degeneration, myelin remnants and thinly myelinated axons were exhibited in Group 3 rats. whereas severe axonal loss, myelin degeneration, regenerative clusters and endoneural fibrosis were discovered in Group 4. There was a significant difference in the number of myelinated axons among the various groups of rats. Conclusions. Our findings show that chronic alcoholism has a negative influence oil peripheral nerve regeneration associated with a significant decrease in axon number and increased axonal degeneration. (C) 2009 IMSS. Published by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.arcmed.2009.05.006
dc.identifier.endpage330en_US
dc.identifier.issn0188-4409
dc.identifier.issn1873-5487
dc.identifier.issue5en_US
dc.identifier.pmid19766893en_US
dc.identifier.scopus2-s2.0-70349151671en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage325en_US
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2009.05.006
dc.identifier.urihttps://hdl.handle.net/11616/94871
dc.identifier.volume40en_US
dc.identifier.wosWOS:000270581100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeripheral nerveen_US
dc.subjectAlcoholismen_US
dc.subjectEthanolen_US
dc.titleImpairment of Peripheral Nerve Healing After Nerve Repair in Rats Chronically Exposed To Alcoholen_US
dc.typeArticleen_US

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