NGAL and NT-proBNP levels in diabetic patients with macroproteinuria

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dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authoridulutas, ozkan/0000-0002-2155-8340
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridtaskapan, hulya/0000-0001-8736-4779
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.authorwosidulutas, ozkan/ABI-6332-2020
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidtaskapan, hulya/ABI-7737-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.contributor.authorTaskapan, Hulya
dc.contributor.authorTaskapan, Mehmet Cagatay
dc.contributor.authorOrman, Ibrahim
dc.contributor.authorUlutas, Ozkan
dc.contributor.authorYigit, Ali
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorYologlu, Saim
dc.date.accessioned2024-08-04T20:37:51Z
dc.date.available2024-08-04T20:37:51Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: In patients with heart failure plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are correlated to urine neutrophil gelatinase-associated lipocalin (NGAL) levels. We prospectively evaluated the relationship among glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (ACR), urine and serum NGAL and NT-proBNP levels in 20 type II diabetic patients with macroalbuminuria at 4-month intervals. Results: Compared with 20 age, gender-matched healthy controls, diabetic patients had higher urine and serum NGAL, serum NT-proBNP and lower eGFR. The eGFR of the patients at the baseline, the 4th and the 8th month were 29.6 +/- 12.0, 27.8 +/- 13.7 and 22.9 +/- 10.4 mL/min/1.73m(2), respectively. No significant change in urine NGAL levels was detected (p > 0.05), whereas there were significant increases in NT-proBNP, serum NGAL and urine ACR and significant decrease in eGFR as the study progressed (p < 0.05). Both the baseline and the 4th month urine ACR were positively correlated to NT-proBNP levels measured at the same periods (r: 0.451; p: 0.046; r: 0.489; p: 0.029 respectively). In all measurements, urine ACR was negatively correlated to serum albumin levels measured at the same periods (r: -0.792; p: 0.000; r: -0.716; p: 0.000; r: -0.531; p: 0.016 respectively). None of eGFR measurements was correlated with NT-proBNP (p > 0.05). Neither serum NGAL nor urinary NGAL levels are associated with NT-proBNP (p > 0.05). Conclusion: Our findings show an association between NT-proBNP and proteinuria in type II diabetic patients with macroalbuminuria but not with serum and urine NGAL.en_US
dc.description.sponsorshipInonu University Medical Research Centeren_US
dc.description.sponsorshipThis study was supported by Inonu University Medical Research Center.en_US
dc.identifier.doi10.3109/0886022X.2013.824336
dc.identifier.endpage1277en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue9en_US
dc.identifier.pmid23964619en_US
dc.identifier.scopus2-s2.0-84884238255en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1273en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2013.824336
dc.identifier.urihttps://hdl.handle.net/11616/96208
dc.identifier.volume35en_US
dc.identifier.wosWOS:000324403100016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectGFRen_US
dc.subjectmacroproteinuriaen_US
dc.subjectNT-proBNPen_US
dc.subjectNGALen_US
dc.titleNGAL and NT-proBNP levels in diabetic patients with macroproteinuriaen_US
dc.typeArticleen_US

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