Efficacy of micronized flavonoid fraction in healing of clean and infected wounds

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dc.authorscopusid7003344837
dc.authorscopusid8587623600
dc.authorscopusid7103280636
dc.authorscopusid6505496380
dc.authorscopusid7003554497
dc.authorscopusid6602807812
dc.contributor.authorHasanoglu A.
dc.contributor.authorAra C.
dc.contributor.authorOzen S.
dc.contributor.authorKali K.
dc.contributor.authorSenol M.
dc.contributor.authorErtas E.
dc.date.accessioned2024-08-04T20:00:45Z
dc.date.available2024-08-04T20:00:45Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurified micronized flavonoid fraction, comprising 90% diosmin and 10% hesperidin, is basically used as a phelebotonic and vasculoprotector agent. It also has anti-inflammatory and anti-edematous actions. This study was designed to evaluate the efficacy of micronized flavonoid fraction in clean and infectious wounds. Sixty Guinea pigs were separated into 2 main groups and 6 subgroups. The first three groups had clean wounds and the other three groups had infected wounds contaminated with S. aureus. Then these main groups were separated into 3 subgroups. The first subgroups was treated with 60 mg/kg/day micronized flavonoid fraction per oral, the second ones was treated with topical 60 mg/kg/day micronized flavonoid fraction, and the third ones had no treatment. Infected wounds were obtained by contamining the wounds with S. aureus. There were no significant differences in wound healing between the groups that have clean wounds (p > 0.05). In the groups with infected wounds, orally and topically treated guina pigs had accelerated wound healing compared to the untreated control group (p < 0.05), confirmed with surface area measurements and histopathological evaluation. Healing showed no difference between the groups treated orally and topically. This study showed that oral or topical administration of micronized flavonoid fraction in the infected wounds is beneficial, while it has no significant effect in clean wounds.en_US
dc.identifier.doi10.1007/BF01616343
dc.identifier.endpage44en_US
dc.identifier.issn1061-1711
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0035725655en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1007/BF01616343
dc.identifier.urihttps://hdl.handle.net/11616/90976
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer New Yorken_US
dc.relation.ispartofInternational Journal of Angiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectflavonoiden_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectarticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug efficacyen_US
dc.subjectfemaleen_US
dc.subjectguinea pigen_US
dc.subjecthistopathologyen_US
dc.subjectnonhumanen_US
dc.subjectpriority journalen_US
dc.subjectskin surfaceen_US
dc.subjectStaphylococcus aureusen_US
dc.subjecttopical treatmenten_US
dc.subjecttreatment outcomeen_US
dc.subjectwound careen_US
dc.subjectwound healingen_US
dc.subjectwound infectionen_US
dc.titleEfficacy of micronized flavonoid fraction in healing of clean and infected woundsen_US
dc.typeArticleen_US

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