The protective effect of cannabinoid type 2 receptor activation on renal ischemia-reperfusion injury

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridCakir, Murat/0000-0002-2066-829X;
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidCakir, Murat/I-8643-2019
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidDoğanyiğit, Züleyha/AAW-2347-2021
dc.contributor.authorCakir, Murat
dc.contributor.authorTekin, Suat
dc.contributor.authorDoganyigit, Zuleyha
dc.contributor.authorCakan, Pinar
dc.contributor.authorKaymak, Emin
dc.date.accessioned2024-08-04T20:46:44Z
dc.date.available2024-08-04T20:46:44Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractKidney ischemia reperfusion (IR) injury is an important health problem resulting in acute renal failure. After IR, the inflammatory and apoptotic process is triggered. The relation of Cannabinoid type 2 (CB2) receptor with inflammatory and apoptotic process has been determined. The CB2 receptor has been shown to be localized in glomeruli and tubules in human and rat kidney. Activation of CB2 receptor with JWH-133 has been shown to reduce apoptosis and inflammation. In this study, it was investigated whether CB2 activation with selective CB2 receptor agonist JWH-133 was protective against renal IR injury. Male Sprague-Dawley rats were divided into 5 groups (n=45). Bilateral ischemia was treated to the IR group rat's kidneys for 45 min and then reperfusion was performed for 24 h. Three different doses of JWH-133 (0.2, 1 and 5 mg/kg) were administered to the treatment groups at the onset of ischemia. The JWH-133 application at three different doses decreased the glomerular and tubular damage. Additionally, in the renal tissue, nuclear factor-kappa B, tumour necrosis factor alpha, interleukin-1beta, and caspase-3 levels decreased immunohistochemically. Similarly, JWH-133 application decreased the serum tumour necrosis factor alpha, blood urea nitrogen, creatinine, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, Cystatin C, interleukin-18, interleukin-1beta, interleukin-6, and interleukin-10 levels. We found that JWH-133 and CB2 receptor activation had a curative effect against kidney IR damage. JWH-133 may be a new therapeutic agent in preventing kidney IR damage.en_US
dc.description.sponsorshipby Bozok University, Department of Scientific Research Projects [6602b-TF/18-193] Funding Source: Medlineen_US
dc.identifier.doi10.1007/s11010-019-03616-6
dc.identifier.endpage132en_US
dc.identifier.issn0300-8177
dc.identifier.issn1573-4919
dc.identifier.issue1-2en_US
dc.identifier.pmid31446615en_US
dc.identifier.scopus2-s2.0-85070998910en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org/10.1007/s11010-019-03616-6
dc.identifier.urihttps://hdl.handle.net/11616/98920
dc.identifier.volume462en_US
dc.identifier.wosWOS:000494829000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKidneyen_US
dc.subjectCannabinoid type 2 receptoren_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectJWH-133en_US
dc.titleThe protective effect of cannabinoid type 2 receptor activation on renal ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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