Elevated Expression of ADAMTS-12 in Maternal and Umbilical Cord Serum of Placenta Accreta Spectrum

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dc.contributor.authorTaskin, Irmak Icen
dc.date.accessioned2024-08-04T20:53:36Z
dc.date.available2024-08-04T20:53:36Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: We investigated a disintegrin and metalloproteinase with thrombospondin type 1 motif-12 (ADAMTS-12) levels in both fetal umbilical cord and maternal blood of pairs diagnosed with placenta accreta spectrum (PAS).Method: We analyzed ADAMTS-12 level by ELISA in 160 samples that included 30 control pairs (30 maternal and 30 umbilical cord serums), 20 pairs in the placenta previa (PP), and 30 pairs in the PAS group (30 maternal and 30 umbilical cord serums).Results: There were increased serum levels of ADAMTS-12 in maternal serum (p = 0.037) and umbilical cord serum level (p = 0.004) of PAS group compared with the PP and healthy control groups. There was a positive correlation between maternal ADAMTS-12 and fetal ADAMTS-12 serum levels (r = 0.53, p = 0.002).Conclusion: Our findings indicate that ADAMTS-12 could be a -diagnostic biomarker for PAS.en_US
dc.identifier.doi10.1080/15513815.2023.2197057
dc.identifier.endpage650en_US
dc.identifier.issn1551-3815
dc.identifier.issn1551-3823
dc.identifier.issue4en_US
dc.identifier.pmid37039473en_US
dc.identifier.scopus2-s2.0-85152385000en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage642en_US
dc.identifier.urihttps://doi.org/10.1080/15513815.2023.2197057
dc.identifier.urihttps://hdl.handle.net/11616/101288
dc.identifier.volume42en_US
dc.identifier.wosWOS:000969106000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofFetal and Pediatric Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADAMTS-12en_US
dc.subjectmaternal serumen_US
dc.subjectplacenta accreta spectrumen_US
dc.subjectumbilical corden_US
dc.titleElevated Expression of ADAMTS-12 in Maternal and Umbilical Cord Serum of Placenta Accreta Spectrumen_US
dc.typeArticleen_US

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