Synthesis of some new pyridylethylated benzoxa(thia)zolinones with analgesic activitiy

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dc.authoridAKTAY, Goknur/0000-0002-1646-8674
dc.authorwosidGokhan-Kelekci, Nesrin/D-6502-2018
dc.contributor.authorGökhan, N
dc.contributor.authorAktay, G
dc.contributor.authorErdogan, H
dc.date.accessioned2024-08-04T20:14:43Z
dc.date.available2024-08-04T20:14:43Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEighteen new 3-[2-(2-/4-pyridyl)ethyl]benzoxlinone(benzothiazolinone) derivatives were synthesized by reacting 2-/4-vinylpyridine and appropriate benzoxazolinones and benzothiazolinones. The analgsic activities of these compounds were investigated by modified Koster and hot-plate tests. Test results revealed that most of the compounds at 100 mg/kg dose levels have higher analgestic activities than acetylisalicylic acid. Compounds with bromo substituents on the phenyl ring in the 6-position of the main ring seemed to show less activity than those with fluorinated ones. Compound 6b showed remarkably high activity in the hot-plate test, although it was inactive in the Koster test. However compound 3a had statistically significant high peripheral analgesic activity at all doses compared to other compounds, although it was inactive in the hot-plate test.en_US
dc.identifier.endpage132en_US
dc.identifier.issn1300-0527
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-18344413997en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://hdl.handle.net/11616/93908
dc.identifier.volume28en_US
dc.identifier.wosWOS:000220680100014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-benzoxazolinoneen_US
dc.subject2-benzothiazolinoneen_US
dc.subjectacylationen_US
dc.subjectpyridylethylen_US
dc.subjectanalgesic activityen_US
dc.titleSynthesis of some new pyridylethylated benzoxa(thia)zolinones with analgesic activitiyen_US
dc.typeArticleen_US

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