The role of MRS in the differentiation of benign and malignant soft tissue and bone tumors

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dc.authoridKahraman, Bayram/0000-0002-5447-1110
dc.authoridALTINOK, M. Tayfun/0000-0002-8779-9382
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidKahraman, Bayram/HKM-4798-2023
dc.authorwosidALTINOK, M. Tayfun/AAS-7079-2021
dc.contributor.authorDoganay, Selim
dc.contributor.authorAltinok, Tayfun
dc.contributor.authorAlkan, Alpay
dc.contributor.authorKahraman, Bayram
dc.contributor.authorKarakas, Hakki Muammer
dc.date.accessioned2024-08-04T20:35:32Z
dc.date.available2024-08-04T20:35:32Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of our study was to investigate the value of choline in the discrimination of benign and malignant soft tissue and bone tumors. Materials and methods: The study group consisted of thirty subjects with bone or soft tissue tumors larger than 1.5 cm in diameter. The experiments were performed in a 1.5 T MR scanner. Coils were selected according to specific locations. A single-voxel MRS was performed for three different TE (time to echo) (31, 136, 272 ms). The volume of interest was positioned on the brightest enhancement. The presence of a cholin peak on at least 2 of these spectrums was considered as the marker of malignancy. The sensitivity, specificity and accuracy of the MRS in the detection and diagnosis of malignant lesions were calculated. The reproducibility of MRS and histopathological results were tested with kappa statistics. Results: Histopathologically, 18 (60%) of the lesions were classed as malignant whereas 12 (40%) were classed as benign. With MRS, 15 (50%) of these lesions were classed as malignant and 15 (50%) as benign. Two patients who were found spectroscopically to have malignant tumors were shown histopathologically to have benign types. Five patients with an MRS showing a benign type were classed with malignant types in histopathological examinations. MRS had a sensitivity rate of 72.2%, specificity of 83.3%, and an accuracy rate of 76.6% in detecting malignant bone and soft tissue tumors. The interrater reliability of both techniques had a kappa value of 0.533. Conclusions: MRS may help in the differentiation of benign and malignant soft tissue and bone tumors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejrad.2010.12.089
dc.identifier.endpageE37en_US
dc.identifier.issn0720-048X
dc.identifier.issue2en_US
dc.identifier.pmid21376496en_US
dc.identifier.scopus2-s2.0-80052148667en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpageE33en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejrad.2010.12.089
dc.identifier.urihttps://hdl.handle.net/11616/95420
dc.identifier.volume79en_US
dc.identifier.wosWOS:000294292700007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone tumoren_US
dc.subjectSoft tissue tumoren_US
dc.subjectMR spectroscopyen_US
dc.titleThe role of MRS in the differentiation of benign and malignant soft tissue and bone tumorsen_US
dc.typeArticleen_US

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