4-Methylsulfonylbenzyl Substituted N-Heterocyclic Carbene-Ruthenium (II) Complexes: Design, Synthesis, Characterization, and Anticancer Activities

Basit Öğe Kaydı
dc.contributor.authorPasahan, Aziz
dc.contributor.authorTaskin, Irmak Icen
dc.contributor.authorGurses, Canbolat
dc.contributor.authorSever, Meryem Ruveyda
dc.contributor.authorKarabiyik, Hande
dc.contributor.authorKarabiyik, Hasan
dc.contributor.authorGok, Yetkin
dc.date.accessioned2026-04-04T13:37:36Z
dc.date.available2026-04-04T13:37:36Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractIn this study, we report the synthesis and anticancer activities of new ruthenium complexes with N-heterocyclic carbene (NHC) ligands, which are of great significance for drug delivery research. For this reason, 4-methylsulfonylbenzyl-substituted benzimidazole-functionalized Ru(II)NHC complexes were synthesized in our research. The characterization of these new complexes were performed using appropriate spectroscopic methods (1H NMR, 13C NMR, and FT-IR) and elemental analysis techniques. The crystal structure of complex 1c was obtained using single crystal X-ray diffraction. MTT method was used to understand in vitro anticancer activities of the complexes against MCF-7 (breast cancer), HCT-116 (colon cancer), SH-SY5Y (brain cancer), and HeLa (cervical cancer) cell lines. Based on the IC50 values determined by MTT assay, the most effective complex was identified as 1 h. DNA binding analyses were carried out using agarose gel electrophoresis, revealing that 1 h weakly interacted with DNA. Additionally, the effects of 1 h on cell cycle progression and apoptosis in the SH-SY5Y cell line were examined using flow cytometry. The results indicated that 1 h induced G0/G1 phase accumulation and increased apoptotic cell death. These findings suggest that the synthesized complex 1 h has a significant anticancer potential.
dc.description.sponsorshipInonu University Research Fund [IUBAP FDK-2022-2950, FOA-2020-2240, 2010.KB.FEN.13]
dc.description.sponsorshipThe authors thank the Inonu University Faculty of Science Department of Chemistry for the characterization of complexes. This study was financially supported by Inonu University Research Fund (IUBAP FDK-2022-2950 and FOA-2020-2240). The authors thank Dokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13) is also greatly acknowledged.
dc.identifier.doi10.1002/slct.202505574
dc.identifier.issn2365-6549
dc.identifier.issue5
dc.identifier.scopus2-s2.0-105028957434
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1002/slct.202505574
dc.identifier.urihttps://hdl.handle.net/11616/109932
dc.identifier.volume11
dc.identifier.wosWOS:001703775400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectanticancer activity
dc.subjectDNA binding
dc.subjectN-heterocyclic carbene
dc.subjectRu-NHC complexes
dc.subjectX-ray diffraction
dc.title4-Methylsulfonylbenzyl Substituted N-Heterocyclic Carbene-Ruthenium (II) Complexes: Design, Synthesis, Characterization, and Anticancer Activities
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu