Effect of paclitaxel administration on P wave duration and dispersion

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dc.authorscopusid6701345397
dc.authorscopusid57214023386
dc.authorscopusid56265702500
dc.authorscopusid8069927100
dc.authorscopusid7003301157
dc.contributor.authorBarutcu I.
dc.contributor.authorSezgin A.T.
dc.contributor.authorGullu H.
dc.contributor.authorEsen A.M.
dc.contributor.authorOzdemir R.
dc.date.accessioned2024-08-04T19:59:37Z
dc.date.available2024-08-04T19:59:37Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe prototypic taxane paclitaxel, which disrupts tubulin dynamics, has been widely used in the treatment of solid malignancies. However, it has been associated with adverse cardiac effects. Therefore, the effect of the paclitaxel infusion on P wave duration and dispersion (PWD) was investigated. Twelve-lead surface ECG's were recorded twice from 12 patients with breast, ovarian and non-small-cell lung carcinoma: one just before paclitaxel infusion and the other 1 hour after the end of the infusion. The changes in maximum (Pmax) and minimum P wave duration (Pmin) were measured manually and the difference between the two values was defined as PWD. The mean heart rate, Pmin, did not change after the infusion. However, Pmax, PWD and the average P wave duration significantly increased after infusion (122 ± 5 vs. 125 ± 5 p = 0.001 and 46 ± 7 vs. 53 ± 9 p = 0.03, 97 ± 5 vs. 101 ± 5 ms p = 0.02 respectively). We found that paclitaxel infusion increased PWD and this may be a result of the drug's effect on cardiac autonomic modulation.en_US
dc.identifier.doi10.1007/s10286-004-0164-4
dc.identifier.endpage38en_US
dc.identifier.issn0959-9851
dc.identifier.issue1en_US
dc.identifier.pmid15045599en_US
dc.identifier.scopus2-s2.0-1842451859en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage34en_US
dc.identifier.urihttps://doi.org/10.1007/s10286-004-0164-4
dc.identifier.urihttps://hdl.handle.net/11616/90751
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofClinical Autonomic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArrhythmiaen_US
dc.subjectP wave dispersionen_US
dc.subjectPaclitaxelen_US
dc.titleEffect of paclitaxel administration on P wave duration and dispersionen_US
dc.typeArticleen_US

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