Does ferritin level affect the outcomes of autologous stem cell transplantation equally in all diseases?

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dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridBİÇİM, SOYKAN/0000-0001-7498-344X
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridUYSAL, AYŞE/0000-0002-5581-8104
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidBİÇİM, SOYKAN/ACZ-6163-2022
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidUYSAL, AYŞE/HJB-3073-2022
dc.authorwosidKAYA, Emin/W-2951-2017
dc.contributor.authorUysal, Ayse
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorSarici, Ahmet
dc.contributor.authorBerber, Ilhami
dc.contributor.authorBicim, Soykan
dc.date.accessioned2024-08-04T20:53:27Z
dc.date.available2024-08-04T20:53:27Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: In this retrospective study, we evaluated the effect of ferritin levels on the outcomes of autologous stem cell transplantation in patients with MM or lymphoma.Methods: In this study, 170 patients with measured ferritin levels within one month before transplantation who underwent ASCT with the diagnosis of MM or lymphoma were evaluated. The cut-off value of ferritin was determined as 500 ng/mL to evaluate the transplant outcomes in both groups. The hematological recovery status/duration, febrile neutropenia rate, hospitalization time, transplant-related mortality (TRM) in the first 100 days, and OS were evaluated according to the ferritin levelResults: Of all patients, 105 (61,8%) were diagnosed with MM and 65 (38.2%) with lymphoma. Ferritin levels had no statistically significant effect on the engraftment status/times, the febrile neutropenia rates, and hospitalization times of both lymphoma and myeloma patients (p > .05). Ferritin level was not significantly associated with TRM in MM (p = .224). However, in lymphoma, ferritin level was significantly associated with TRM (33.3% for ferritin level & GE;500 ng/L vs. 5.3% for ferritin level ng/mL, p = .005). There was no statistically significant correlation between ferritin value and OS in MM group [ferritin level & GE; 500 ng/L: 39.9 months (95% CI: 33.7-46.1) and ferritin level 500 ng/mL: 39.4 months (95% CI: 36.5-42.2), p = .446]. Ferritin level was significantly associated with OS in patients with lymphoma [ferritin level & GE; 500 ng/L: 22.1 months 95% CI: 14.7-29.5), ferritin level 500 ng/mL: 27.3 months (95% CI: 22.4-32.2), p = .038]Conclusion: High ferritin level is important prognostic factor on survival after ASCT in patients with lymphoma.en_US
dc.identifier.doi10.1016/j.transci.2023.103655
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue3en_US
dc.identifier.pmid36805278en_US
dc.identifier.scopus2-s2.0-85148721612en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2023.103655
dc.identifier.urihttps://hdl.handle.net/11616/101187
dc.identifier.volume62en_US
dc.identifier.wosWOS:001015429700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutologous stem cell transplantationen_US
dc.subjectFerritinen_US
dc.subjectLymphomaen_US
dc.subjectMultiple myelomaen_US
dc.titleDoes ferritin level affect the outcomes of autologous stem cell transplantation equally in all diseases?en_US
dc.typeArticleen_US

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