Superior Electrochemical Sensor Application of Co3O4/C Heterostructure in Rapid Analysis of Anticancer Drug Palbociclib in Pharmaceutical Formulations and Biological Fluids

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dc.contributor.authorVural, Ozgul
dc.contributor.authorBugday, Nesrin
dc.contributor.authorGenc, Asena Ayse
dc.contributor.authorErk, Nevin
dc.contributor.authorDuygulu, Ozgur
dc.contributor.authorYasar, Sedat
dc.date.accessioned2026-04-04T13:34:44Z
dc.date.available2026-04-04T13:34:44Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractIn this work, we report a study examining how different salt concentrations affect the structure and electrochemical performance of two Co3O4/C materials designed for the fabrication of an easy, cheap, fast, safe, and useful electrochemical sensor for the detection of Palbociclib (PLB). Co3O4 nanoparticles were successfully created by encapsulating them in N-doped amorphous carbon matrices by using the molten salt-assisted approach. In this process, different amounts of potassium iodate and zeolitic imidazolate framework-12 (ZIF-12) were used, followed by pyrolysis at 800 degrees C. Optimum Co3O4 embedded porous carbon structures were obtained, and the composite with the highest electrochemical properties was modified to a glassy carbon electrode (GCE) surface for PLB detection. The linear response spanned from 1.0 to 5.0 mu M, featuring a limit of detection (LOD) of 0.122 mu M and a limit of quantification (LOQ) of 0.408 mu M; the correlation coefficient was calculated as 0.995. The high sensitivity of the method in detecting PLB in pharmaceutical samples and human urine demonstrated its feasibility, with recovery percentages ranging from 99.3% to 101.3% and relative standard deviation (RSD) values of <3%. Therefore, this technique will make a significant contribution to monitoring and improving existing cancer treatment options.
dc.description.sponsorshipAnkara University [TSA-2023-2738, TDK-2023-3036/TDK-2023-3039, TDK-2024-3126]; Inonu University Scientific Research [FBG-2023-3310]
dc.description.sponsorshipThe authors expressed their gratitude to the Researchers who supported the Ankara University Scientific Research Project Nos. TSA-2023-2738, TDK-2023-3036/TDK-2023-3039, TDK-2024-3126 and the Inonu University Scientific Research Project No. FBG-2023-3310. This article was prepared within the scope of Ozgul Vural's doctoral thesis conducted at Ankara University's Health Sciences Institute.
dc.identifier.doi10.1021/acs.langmuir.4c02551
dc.identifier.endpage21151
dc.identifier.issn0743-7463
dc.identifier.issn1520-5827
dc.identifier.issue40
dc.identifier.orcid0000-0001-5366-9275
dc.identifier.orcid0000-0001-8646-0363
dc.identifier.orcid0000-0001-7285-2761
dc.identifier.pmid39340460
dc.identifier.scopus2-s2.0-85205815514
dc.identifier.scopusqualityQ1
dc.identifier.startpage21139
dc.identifier.urihttps://doi.org/10.1021/acs.langmuir.4c02551
dc.identifier.urihttps://hdl.handle.net/11616/109371
dc.identifier.volume40
dc.identifier.wosWOS:001324856000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofLangmuir
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectSensitive Voltammetric Sensor
dc.subjectCarbon-Paste Electrode
dc.subjectAscorbic-Acid
dc.subjectUric-Acid
dc.subjectComposite
dc.subjectNanocomposites
dc.subjectOptimization
dc.subjectValidation
dc.subjectDopamine
dc.subjectDots
dc.titleSuperior Electrochemical Sensor Application of Co3O4/C Heterostructure in Rapid Analysis of Anticancer Drug Palbociclib in Pharmaceutical Formulations and Biological Fluids
dc.typeArticle

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