Synthesis and biological evaluation of Au-NHC complexes

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dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridAygün, Muhittin/0000-0001-9670-9062
dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridAKKOÇ, Mitat/0000-0001-8641-8958
dc.authoridKhan, Siraj/0000-0003-1948-452X
dc.authoridyasar, sedat/0000-0001-7285-2761
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidAygün, Muhittin/P-3605-2019
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidAKKOÇ, Mitat/AAJ-5780-2020
dc.contributor.authorEkinci, Orhan
dc.contributor.authorAkkoc, Mitat
dc.contributor.authorKhan, Siraj
dc.contributor.authorYasar, Sedat
dc.contributor.authorGurses, Canbolat
dc.contributor.authorNoma, Samir
dc.contributor.authorBalcioglu, Sevgi
dc.date.accessioned2024-08-04T20:52:08Z
dc.date.available2024-08-04T20:52:08Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNew seven Au-N-heterocyclic carbene (NHC) complexes have been synthesized via transmetalation from Ag-NHC complexes. NHC salts, Ag-NHC, and Au-NHC complexes were fully characterized by widely used spectroscopic techniques. The molecular and crystal structures of 3b and 3f Au-NHC complexes were clarified through the single-crystal X-ray diffraction method. According to X-ray diffraction analysis results, the coordination geometry around Au(I) atoms in the complexes are revealed to be almost linear with C-Au-Cl angle. Anticancer activity, DNA binding, xanthine oxidase (XO) inhibitory activity studies, and molecular docking studies were evaluated for all Au-NHC complexes to explore the binding mechanism at the active site. The IC50 value of Au-NHC complexes against human colorectal cancer (Caco-2) and breast cancer (MCF-7) cell lines was defined by MTT assay. The IC50 values for MCF-7 in the range of 5.2 +/- 2 to 152.4 +/- 1 mu M and Caco-2 5.2 +/- 1 to 152.7 +/- 2 mu M showed that 3a, 3b, 3c, 3d, and 3g have better anticancer activity than Cisplatin incredibly complex 3a against both cancer cell line. All Au-NHC complexes showed excellent antimicrobial activity against different bacteria and fungi. 3a was the complex that exhibited the best antimicrobial activity here as well. The XO inhibitory activity experimental results indicated that all gold complexes showed remarkable inhibition activity against XO compared to the generally used standard, allopurinol. The range of IC50 value was determined from 0.407 to 2.681 mu M. 3d complex showed the lowest IC50 value at 0.407 mu M. DNA binding experiments were performed using agarose gel electrophoresis to observe the ability of synthesized Au-NHC complexes to interact with the supercoiled pUC19 plasmid DNA. Molecular docking studies were performed to determine the binding mode of all active compounds against the XO enzyme, antibacterial, antifungal, and MCF-7 cell lines.en_US
dc.description.sponsorshipInonu universitesi [FBG-2021-2562]; Dokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer [2010.KB.FEN.13]en_US
dc.description.sponsorshipThis work was financially supported by Inonu universitesi (Project No: FBG-2021-2562) and thanks to Dokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13).en_US
dc.identifier.doi10.1002/aoc.6811
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85134166484en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/aoc.6811
dc.identifier.urihttps://hdl.handle.net/11616/100781
dc.identifier.volume36en_US
dc.identifier.wosWOS:000826786500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofApplied Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanticancer activityen_US
dc.subjectau-NHCen_US
dc.subjectDNA bindingen_US
dc.subjectmolecular dockingen_US
dc.subjectxanthine oxidaseen_US
dc.titleSynthesis and biological evaluation of Au-NHC complexesen_US
dc.typeArticleen_US

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