Potential salvage therapy for accidental intrathecal vincristine administration

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dc.authoridKutlu, Nurettin Onur/0000-0002-3306-6570
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authorwosidKutlu, Nurettin Onur/AAW-6196-2021
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.contributor.authorÖzgen, Ü
dc.contributor.authorSoylu, H
dc.contributor.authorÖnal, SÇ
dc.contributor.authorMizrak, B
dc.contributor.authorTürköz, Y
dc.contributor.authorKutlu, NO
dc.contributor.authorKoçak, A
dc.date.accessioned2024-08-04T20:12:07Z
dc.date.available2024-08-04T20:12:07Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Accidental intrathecal vincristine (VCR) administration results in severe neurotoxicity, usually fatal in outcome. No specific therapy for initrathecal VCR toxicity has been reported so far. In our recent report, complete in vitro degradation of VCR by hypochlorous acid (HOCl) was demonstrated. Methods: In this comparative study, we examined the in vivo effectivity of HOCl in the cerebrospinal fluid of 24 New Zealand rabbits following intracisternal VCR administration. Results: There were no significant clinical or histopathologic abnormalities in the control and HOCl groups; however, multiple necrotic foci on histopathological examination of brain sections in the VCR group were determined. There were significantly lower numbers of necrotic foci in brain sections of rabbits which received HOCl administration than those without therapy. Conclusion: Our results indicate that HOCl may reduce VCR neurotoxicity. Copyright (C) 2000 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000007305
dc.identifier.endpage326en_US
dc.identifier.issn0009-3157
dc.identifier.issue5en_US
dc.identifier.pmid10965097en_US
dc.identifier.scopus2-s2.0-0033798322en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage322en_US
dc.identifier.urihttps://doi.org/10.1159/000007305
dc.identifier.urihttps://hdl.handle.net/11616/93225
dc.identifier.volume46en_US
dc.identifier.wosWOS:000089009300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofChemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintrathecal vincristineen_US
dc.subjectHOClen_US
dc.subjectneurotoxicityen_US
dc.subjectbrainen_US
dc.subjectrabbitsen_US
dc.titlePotential salvage therapy for accidental intrathecal vincristine administrationen_US
dc.typeArticleen_US

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