Adrenomedullin and leptin levels in diabetic retinopathy and retinal diseases

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorEr, H
dc.contributor.authorDoganay, S
dc.contributor.authorÖzerol, E
dc.contributor.authorYürekli, M
dc.date.accessioned2024-08-04T20:13:50Z
dc.date.available2024-08-04T20:13:50Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Proliferative and vascular retinal diseases are important cause of irreversible blindness. Consistent features of these diseases are endothelial dysfunction and angiogenesis. Adrenomedullin (ADM) is a multifunctional vasorelaxant peptide. Leptin is a recently discovered metabolic peptide that regulates energy metabolism in human In the present study, we aimed to investigate the possible roles of adrenomedullin and leptin in the pathophysiology of diabetic and proliferative diseases. Methods: Ten patients with proliferative diabetic retinopathy (57.1 years, 5 female and 5 male) and 8 patients (51 years, 5 female and 3 male) with other retinal diseases including macular hole and epiretinal membrane were included in this study. All the patients had undergone pars plana vitrectomy for complications of the diseases. Vitreous samples were collected by vitreous tap during the vitrectomy. Adrenomedullin analysis was made by using reverse-phase high-performance liquid chromatography (HPLC). Leptin was measured by enzyme-linked immunosorbent assay (ELISA). Body mass index (BMI) [weight (kg)/height (m(2))] was calculated for each group. The Mann-Whitney U test was used for statistics. Results: The age, gender ratio and BMI were not substantially different between the two groups. The mean vitreous adrenomedullin levels (63.9 +/- 7.1 pmol/l) were significantly higher (p < 0.05) in group I than in group II (34.25 +/- 3.0 pmol/l). Leptin levels in vitreous (4.54 +/- 1.6 ng/ml) were also significantly higher (p < 0.05) in patients with diabetic retinopathy than in those without diabetes (1.83 +/- 0.5 ng/ml). Conclusion: Increased adrenomedullin and leptin levels in vitreous humor might be a possible newly associated factor in the course of vascular and proliferative retinal diseases. Copyright (C) 2005 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000083270
dc.identifier.endpage111en_US
dc.identifier.issn0030-3755
dc.identifier.issn1423-0267
dc.identifier.issue2en_US
dc.identifier.pmid15802936en_US
dc.identifier.scopus2-s2.0-17244380698en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.1159/000083270
dc.identifier.urihttps://hdl.handle.net/11616/93884
dc.identifier.volume219en_US
dc.identifier.wosWOS:000227989000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOphthalmologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectdiabetic retinopathyen_US
dc.subjectleptinen_US
dc.subjectproliferative vitreoretinopathyen_US
dc.titleAdrenomedullin and leptin levels in diabetic retinopathy and retinal diseasesen_US
dc.typeArticleen_US

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