Potential toxicity of mitomycin C and 5-fluorouracili: An experimental study

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dc.authorscopusid6504654282
dc.authorscopusid20133975300
dc.authorscopusid56108998400
dc.authorscopusid6701335627
dc.contributor.authorTilgen F.
dc.contributor.authorEr H.
dc.contributor.authorMizrak B.
dc.contributor.authorHepsen I.F.
dc.date.accessioned2024-08-04T19:59:16Z
dc.date.available2024-08-04T19:59:16Z
dc.date.issued1997
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose. To investigate potential loxicities of mitomycin C (MMC) and 5-Fluorouracil (5-FU) histologically after administration of subconjunctivally in 8 rabbits. Methods. In group 1 (8 eyes), the right eye of 4 rabbits received a single dose of 0.2 mL subconjunctival injection of O.I. 0.2, 0.4 and 0.6 nig/ mL and an equal volume of sterile saline in the left eye. In group 2, (8 eyes) 0.2 mL subconjunctival injection of 10.0 mg/mL 5-FU and 25 mg/mL 5-FU were performed in the right eye and in the left eye once daily for 5 days, respectively. The rabbits were killed at !, 20, 30, and 45 days after the last injections, the eyes were enucleated and studied histologically using light microscopy. Results. The congestion and edema in the ciliary body and iris, polymorphonuclear leukocytes (PMNs) infiltration at the limbus, and atrophy in the extraocular muscle were prominent in eyes injected, especially, 0.4 and 0.6 mg/mL MMC than the 5-FUinjected eyes. Conclusions. Subconjunctival injection of MMC even at moderate concentrations can be toxic to the ciliary body, thus a safe dose of a single subconjunctival injection of MMC appears to be 0.1 mg/mL or less. 5-FU is also required to use of much lower total dose of subconjunctival then used in the clinica! trial.en_US
dc.identifier.issn0146-0404
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-33749211698en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://hdl.handle.net/11616/90510
dc.identifier.volume38en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titlePotential toxicity of mitomycin C and 5-fluorouracili: An experimental studyen_US
dc.typeArticleen_US

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