Significance of serum trace element status in patients with rheumatic heart disease - A prospective study

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dc.authorwosidkucukbay, fatumetuzzehra/X-5743-2019
dc.contributor.authorKosar, F
dc.contributor.authorSahin, I
dc.contributor.authorAcikgöz, N
dc.contributor.authorAksoy, Y
dc.contributor.authorKüçükbay, FZ
dc.contributor.authorCehreli, S
dc.date.accessioned2024-08-04T20:14:59Z
dc.date.available2024-08-04T20:14:59Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients had significantly lower serum concentrations of Se and Zn than control subjects (p < 0.05 and p < 0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93 +/- 0.59 mu g/L vs 1.06 +/- 0.29 mu g/L; p < 0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70 +/- 0.92 vs 1.68 +/- 0.45; p < 0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity classes (p > 0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease.en_US
dc.identifier.doi10.1385/BTER:107:1:001
dc.identifier.endpage9en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid16170217en_US
dc.identifier.scopus2-s2.0-24944529927en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1385/BTER:107:1:001
dc.identifier.urihttps://hdl.handle.net/11616/94095
dc.identifier.volume107en_US
dc.identifier.wosWOS:000232464200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectrheumatic heart diseaseen_US
dc.subjecttrace elementen_US
dc.subjectseleniumen_US
dc.subjectzincen_US
dc.subjectcopperen_US
dc.titleSignificance of serum trace element status in patients with rheumatic heart disease - A prospective studyen_US
dc.typeArticleen_US

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