Protective effects of quercetin and chrysin against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative stress, body wasting and altered cytokine productions in rats

Simple item page
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Ilknur
dc.date.accessioned2024-08-04T20:35:32Z
dc.date.available2024-08-04T20:35:32Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the effects of the quercetin (Q) and chrysin (CH) on oxidative stress, cytokines levels and body weights in rats induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were divided randomly into six equal groups. TCDD, Q and CH were administered by gavages dissolved in corn oil at the doses of 2 mu g/kg/week, 20 mg/kg/day and 50 mg/kg/day, respectively. The blood samples were taken from all rats at 60th days to be analyzed for the determination of thiobarbituric acid reactive substances (TBARS), tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). The results indicated that although TCDD increased significantly TBARS and TNF-alpha levels, it caused a decline in the levels of IFN-gamma and body weight. In contrast, these effects of TCDD on TBARS, TNF-alpha, IFN-gamma levels and body weight were significantly prevented by treatments of Q and CH. In conclusion, it was determined that TCDD caused the adverse effects on immune functions, body weight and oxidative stress in rats. However, Q and CH administered with TCDD eliminated these adverse effects. These results suggest that Q and CH may play a protective role against TCDD toxicity.en_US
dc.description.sponsorshipIUBAP (Inonu University) [2009/24]en_US
dc.description.sponsorshipWe acknowledge the support of IUBAP (Scientific Research Fund of Inonu University) under grant 2009/24.en_US
dc.identifier.doi10.3109/08923973.2010.543686
dc.identifier.endpage508en_US
dc.identifier.issn0892-3973
dc.identifier.issn1532-2513
dc.identifier.issue3en_US
dc.identifier.pmid21214421en_US
dc.identifier.scopus2-s2.0-79961147782en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage504en_US
dc.identifier.urihttps://doi.org/10.3109/08923973.2010.543686
dc.identifier.urihttps://hdl.handle.net/11616/95397
dc.identifier.volume33en_US
dc.identifier.wosWOS:000293528300016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofImmunopharmacology and Immunotoxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTCDDen_US
dc.subjectquercetinen_US
dc.subjectchrysinen_US
dc.subjectcytokineen_US
dc.subjectbody weighten_US
dc.subjectoxidative stressen_US
dc.titleProtective effects of quercetin and chrysin against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative stress, body wasting and altered cytokine productions in ratsen_US
dc.typeArticleen_US

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize