Laparoscopic endometrioma resection increases peri-implantation endometrial HOXA-10 and HOXA-11 mRNA expression

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dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridUnlu, Mehmet Cihat/0000-0001-5507-3993
dc.authorwosidCaliskan, Eray/HTR-8541-2023
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidUnlu, Mehmet Cihat/Q-5146-2018
dc.contributor.authorCelik, Onder
dc.contributor.authorUnlu, Cihat
dc.contributor.authorOtlu, Baris
dc.contributor.authorCelik, Nilufer
dc.contributor.authorCaliskan, Eray
dc.date.accessioned2024-08-04T20:40:22Z
dc.date.available2024-08-04T20:40:22Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To determine whether laparoscopic endometrioma resection alters peri-implantation endometrial HOXA-10, HOXA-11, LIF, ITGB3 and ITGAV mRNA expression. Design: Case-control study. Setting: Medical school. Patient(s): Twenty infertile patients with uni-or bilateral endometrioma, five infertile patients having nonendometriotic benign ovarian cyst, and five fertile control subjects. Intervention(s): Mid-luteal-phase endometrial sampling was performed at the time of surgery. Second endometrial biopsies were obtained 3 months after laparoscopic endometrioma resection during the mid-luteal phase of the cycle. Main Outcome Measure(s): Endometrial HOXA-10, HOXA-11, LIF, ITGAV, and ITGB3 mRNA expressions were evaluated with the use of reverse-transcription polymerase chain reaction. Result(s): Significantly decreased endometrial ITGAV mRNA expression was noted in biopsies obtained from endometrioma and nonendometriotic cyst groups before surgery. Trends toward decreased endometrial HOXA-10, HOXA-11, LIF, and ITGB3 mRNA expressions were noted in the endometrioma and nonendometriotic cyst groups before surgery compared with the fertile subjects. However, the differences failed to show statistical significance. Compared with preoperative values, significantly increased HOXA-10 (12.1-fold change) and HOXA-11 (17.2-fold change) mRNA expressions were noted in endometrial biopsies obtained from subjects who were undergoing endometrioma surgery. Fold change in endometrial ITGAV mRNA after endometrioma surgery was found to be 30.1 and indicated a positive regulation. However, this fold increase was statistically insignificant. Expressions of these endometrial receptivity markers did not change significantly after surgical removal of nonendometriotic benign ovarian cysts. Conclusion(s): Laparoscopic endometrioma resection increases peri-implantation endometrial HOXA-10 and HOXA-11 mRNA expression, suggesting an improvement in endometrial receptivity. (C) 2015 by American Society for Reproductive Medicine.en_US
dc.description.sponsorshipTurkish German Gynecologic Research and Education Foundationen_US
dc.description.sponsorshipSupported by the Turkish German Gynecologic Research and Education Foundation.en_US
dc.identifier.doi10.1016/j.fertnstert.2015.04.041
dc.identifier.endpage365en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue2en_US
dc.identifier.pmid26056923en_US
dc.identifier.scopus2-s2.0-84938293296en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage356en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2015.04.041
dc.identifier.urihttps://hdl.handle.net/11616/96884
dc.identifier.volume104en_US
dc.identifier.wosWOS:000363954000018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriomaen_US
dc.subjecteutopic endometriumen_US
dc.subjectlaparoscopyen_US
dc.subjecthomeobox genesen_US
dc.titleLaparoscopic endometrioma resection increases peri-implantation endometrial HOXA-10 and HOXA-11 mRNA expressionen_US
dc.typeArticleen_US

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