Comparison of Fibrinolytic versus Surgical Therapy in the Treatment of Obstructive Prosthetic Valve Thrombosis: A Single-Center Experience

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dc.authorwosidErmis, Necip/HJP-7061-2023
dc.authorwosidAltay, Hakan/AAE-1392-2021
dc.authorwosidErmis, Necip/A-5184-2018
dc.authorwosidBilgi, Muhammet/JAX-7104-2023
dc.contributor.authorErmis, Necip
dc.contributor.authorAtalay, Hakan
dc.contributor.authorAltay, Hakan
dc.contributor.authorBilgi, Muhammet
dc.contributor.authorBinici, Suleyman
dc.contributor.authorSezgin, Alpay T.
dc.date.accessioned2024-08-04T20:32:49Z
dc.date.available2024-08-04T20:32:49Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Prosthetic heart valve thrombosis (PVT) is a rare but severe cardiac condition. There are only a few data regarding comparison of the fibrinolytic and surgical approaches for the treatment of PVT. In this study, we compared the results of fibrinolytic therapy versus surgery in patients who presented to our institution with a diagnosis of obstructive-type PVT. Methods: From January 2001 to August 2008 in our institution, 33 patients who met clinical and echocardiographic criteria for obstructive-type PVT were included in the study. Fifteen of these patients underwent fibrinolytic treatment with streptokinase, which consisted of an initial bolus of 250,000 U followed by 100,000 U/h. Eighteen patients were treated with surgery. Results: The 2 groups had similar baseline characteristics, including New York Heart Association functional status, types and positions of prosthetic valves, international normalized ratio values, and presentation symptoms. Full hemodynamic success was achieved in 12 patients who underwent fibrinolytic therapy and in 15 patients in the surgery group. The mean (+/- SD) streptokinase infusion time was 17.8 +/- 11.1 hours. Two major hemorrhages and 2 cases of systemic embolism were observed in the fibrinolytic group. The 2 groups did not differ with respect to mortality rate (P = .79). The duration of hospitalization was longer in the fibrinolytic group than in the surgery group (10.7 +/- 6.6 days versus 6.9 +/- 6.7 days, P = .045). Conclusions: Although fibrinolytic therapy is generally recommended for the treatment of PVT for specific patient groups, our results suggest that it may be as efficacious and safe as surgery, depending on patient selection.en_US
dc.identifier.doi10.1532/HSF98.20101062
dc.identifier.endpageE92en_US
dc.identifier.issn1098-3511
dc.identifier.issn1522-6662
dc.identifier.issue2en_US
dc.identifier.pmid21521682en_US
dc.identifier.scopus2-s2.0-79955634838en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE87en_US
dc.identifier.urihttps://doi.org/10.1532/HSF98.20101062
dc.identifier.urihttps://hdl.handle.net/11616/95316
dc.identifier.volume14en_US
dc.identifier.wosWOS:000545412500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherForum Multimedia Publishing, Llcen_US
dc.relation.ispartofHeart Surgery Forumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keywords]en_US
dc.titleComparison of Fibrinolytic versus Surgical Therapy in the Treatment of Obstructive Prosthetic Valve Thrombosis: A Single-Center Experienceen_US
dc.typeArticleen_US

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