Use of caffeic acid phenethyl ester and cortisone may prevent proliferative vitreoretinopathy

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorTurkoz, Y
dc.contributor.authorEr, H
dc.contributor.authorBorazan, M
dc.contributor.authorYilmaz, H
dc.contributor.authorMizrak, B
dc.contributor.authorParlakpinar, H
dc.contributor.authorCigremis, Y
dc.date.accessioned2024-08-04T20:15:02Z
dc.date.available2024-08-04T20:15:02Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To investigate whether caffeic acid phenethyl ester ( CAPE) and cortisone prevent proliferative vitreoretinopathy (PVR). Methods: Twenty pigmented rabbits were used in this study. All rabbits except controls received an intravitreal injection of 0.15 ml (75,000 U) of platelet-rich plasma into their left eye. The animals were divided into four groups: group I was treated with intraperitoneal injection of 0.5 ml (15 mumol/kg) of CAPE for 3 days, group II received 0.15 ml (4 mg/kg) of intravitreal cortisone, group III received nothing ( blank group), and group IV ( control group) received only 1 ml of 1% ethanol intraperitoneally daily for 3 days. Proliferative changes were graded in a masked fashion by indirect ophthalmoscopy for a 15-day follow-up period. The malondialdehyde (MDA), reduced glutathione (GSH) and total nitrite ( NO) levels were measured in the vitreous humor. Results: The grades of PVR were B - C in group I, and C - D in group II. The PVR grade in the control group was C - D. The mean MDA level in group I (4.0 +/- 0.8 mumol/l) was significantly lower than in the blank group (6.0 mumol/l) (p< 0.05). The mean GSH level in group I (71.0 +/- 11.2 mu mol/l) was significantly different than in the blank group (p< 0.05). The MDA and GSH levels in group II were 4.7 +/- 0.6 mumol/l and 53.8 +/- 7.8 mumol/l, respectively. Both these levels were not significantly different from the blank group (p > 0.05). The NO levels in both treatment groups were significantly lower than in the blank group ( p< 0.001). Conclusion: These findings suggest an inhibitory effect of CAPE on PVR. The inhibitory effect was supported by lower MDA and NO with higher GSH levels in treatment groups than in the blank group. There was no detected significant effect of cortisone for preventing PVR experimentally.en_US
dc.identifier.doi10.1080/09629350410001688512
dc.identifier.endpage130en_US
dc.identifier.issn0962-9351
dc.identifier.issn1466-1861
dc.identifier.issue2en_US
dc.identifier.pmid15203555en_US
dc.identifier.scopus2-s2.0-2542510788en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.1080/09629350410001688512
dc.identifier.urihttps://hdl.handle.net/11616/94104
dc.identifier.volume13en_US
dc.identifier.wosWOS:000221262400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofMediators of Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectcortisone proliferative vitreoretinopathyen_US
dc.titleUse of caffeic acid phenethyl ester and cortisone may prevent proliferative vitreoretinopathyen_US
dc.typeArticleen_US

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