A silent outbreak due to Klebsiella pneumoniae that co-produced NDM-1 and OXA-48 carbapenemases, and infection control measures

Basit Öğe Kaydı
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridtoplu, sibel altunışık/0000-0002-2915-4666
dc.authoridDuman, Yucel/0000-0002-9090-2096
dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidtoplu, sibel altunışık/ABH-5816-2020
dc.authorwosidDuman, Yucel/AAU-6221-2020
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.contributor.authorDuman, Yucel
dc.contributor.authorErsoy, Yasemin
dc.contributor.authorGursoy, Nafia Canan
dc.contributor.authorToplu, Sibel Altunisik
dc.contributor.authorOtlu, Baris
dc.date.accessioned2024-08-04T20:47:12Z
dc.date.available2024-08-04T20:47:12Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective(s): ): Infections due to carbapenemase-producing Klebsiella pneumoniae are associated with high morbidity and mortality. In this study, we report a hospital outbreak due to co-producing OXA-48 and NDM-1 K. pneumoniae clone. The aim of the study is to investigate the clonal relationship of strains, risk factors of outbreak and infection control measures. Materials and Methods: Once an outbreak was suspected at the end of December 2017 in our intensive care unit (ICU), carbapenem resistance K. pneumoniae identified in patients' specimens. An outbreak analysis was begun to determine the risk factors and dissemination of the cases. A case-control study was conducted to determine the risk factors. To control the outbreak; tight contact prevention, good clean-up the medical devices and hospital environment, were done. Staff training programs such as hand hygiene, disinfection, wearing aprons, good cleaning were created. Carbapenem resistance genes determined by PCR. Clonal relationships of strains investigated by PFGE. Results: We investigate 21 carbapenem-resistant K. pneumonia strains. Nine of them were found co-produced NDM-1 and OXA-48, 11 strains produced OXA-48, and one strain produced NDM-1. Seven strains of co-producing NDM-1 and OXA-48 were found clonally related with PFGE. We could not determine any risk factor except rectal colonization in the case-control study. Conclusion: The interventions that successfully controlled this outbreak were hand hygiene, tight contact prevention, good clean-up of the hospital environment and medical devices. As a result, we believe that it would be beneficial to take infection control measures to prevent the spread of these strains to the community and hospital settings.en_US
dc.identifier.doi10.22038/IJBMS.2019.35269.8400
dc.identifier.endpage50en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue1en_US
dc.identifier.pmid32405347en_US
dc.identifier.scopus2-s2.0-85080114675en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2019.35269.8400
dc.identifier.urihttps://hdl.handle.net/11616/99204
dc.identifier.volume23en_US
dc.identifier.wosWOS:000498871600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbapenemaseen_US
dc.subjectKlebsiella pneumoniaeen_US
dc.subjectNDMen_US
dc.subjectOXA-48en_US
dc.subjectOutbreaken_US
dc.titleA silent outbreak due to Klebsiella pneumoniae that co-produced NDM-1 and OXA-48 carbapenemases, and infection control measuresen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu