Pro-oxidant and antiproliferative effects of the 1,3,4-thiadiazole-based Schiff base and its metal complexes

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dc.authoridYilmaz, Bayram/0000-0002-2674-6535
dc.authoridKaratepe, Mustafa/0000-0001-6358-5913
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridTuran, Nevin/0000-0001-6740-6812
dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authoridŞekerci, Memet/0000-0002-7730-645X
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidYilmaz, Bayram/IXD-3395-2023
dc.authorwosidSekerci, Memet/W-7894-2018
dc.authorwosidKaratepe, Mustafa/HII-5655-2022
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidTuran, Nevin/AAB-8583-2019
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidŞekerci, Memet/AAB-6027-2022
dc.contributor.authorTuran, Nevin
dc.contributor.authorTopcu, M. Fatih
dc.contributor.authorErgin, Zuhal
dc.contributor.authorSandal, Suleyman
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorYilmaz, Bayram
dc.date.accessioned2024-08-04T20:35:33Z
dc.date.available2024-08-04T20:35:33Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAdverse biological activities of Schiff base (SB) derivatives are well known. In this study, the ligand and its metal complexes have been synthesized and characterized by IR, H-1-NMR spectra, elemental analyses, magnetic susceptibility, UV-Vis spectra, and thermogravimetry/differential thermal analysis. From the elemental analyses data, the complexes were proposed to have the general formula [Mn(L)(2) H2O)(2)], [Co(L)(2) H2O)(2)], and [Ni-2(L)(H2O)(4)(Cl)(3)]. From the magnetic moment and UV-Vis spectra data, it was found that the geometrical structures of these complexes are octahedral. In the in vivo experiment, adult male rats were injected subcutaneously with a new SB (L) and its [Mn(L)(2)(H2O)(2)], [Co(L)(2)(H2O)(2)], and [Ni-2(L)(H2O)(4)(Cl)(3)] complexes (25 mg/kg body weight) and were then sacrificed 16 days later. Effects of these compounds on serum antioxidant vitamins (i.e., vitamins A, E, and C) and malondialdehyde (MDA) levels were measured in blood serum, liver, and kidney tissues. In an in vitro experiment, antiproliferative effects of these compounds were assessed on the human breast carcinoma MCF-7 and murine leukemia L1210 cell lines. Serum MDA and vitamins A, E, and C levels did not change by the treatments. However, in the kidney and liver tissues, MDA levels were higher, whereas vitamin levels were lower in treatment groups, compared to the control group. All compounds inhibited cell proliferation of MCF-7 and L1210 cancer cell lines in a dose- and time-dependent manner. In conclusion, SB derivatives tested in the current study induced oxidative stress in vivo and exhibited antiproliferative effects in an in vitro culture system.en_US
dc.description.sponsorshipTUBITAK [104T363]; Firat University Research Foundation [522]en_US
dc.description.sponsorshipThis study was financially supported by TUBITAK (project no.: 104T363). The authors would also like to thank the Firat University Research Foundation for their financial support (FUBAP project no.: 522).en_US
dc.identifier.doi10.3109/01480545.2011.564177
dc.identifier.endpage378en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue4en_US
dc.identifier.pmid21714772en_US
dc.identifier.scopus2-s2.0-80052710275en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://doi.org/10.3109/01480545.2011.564177
dc.identifier.urihttps://hdl.handle.net/11616/95438
dc.identifier.volume34en_US
dc.identifier.wosWOS:000294861800005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1;3;4-thiadiazole-based Schiff baseen_US
dc.subjectantiproliferativeen_US
dc.subjectpro-oxidanten_US
dc.titlePro-oxidant and antiproliferative effects of the 1,3,4-thiadiazole-based Schiff base and its metal complexesen_US
dc.typeArticleen_US

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