Synthesis of Gum Arabic-Based Biopolymer Network and Determination of Its Toxicity Properties in In Vitro - In Vivo Model Systems

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dc.contributor.authorAçarı, İdil Karaca
dc.contributor.authorTurhan, Duygu Özhan
dc.contributor.authorKuruçay, Ali
dc.contributor.authorKöytepe, Süleyman
dc.contributor.authorAteş, Burhan
dc.date.accessioned2024-08-04T19:42:54Z
dc.date.available2024-08-04T19:42:54Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, gum arabic based network polymers were prepared using epoxy functional PEG structures. The basic physicochemical properties of these structures, their structural characterization, thermal properties and morphological properties were investigated. Toxicity properties of constructs synthesized on zebrafish (Danio rerio (Hamilton)) offspring were determined in vivo. In addition, in vitro toxicity tests were performed on L929 fibroblast cells. When the general properties of these structures were examined. Structural and thermal properties were better with increasing cross-linker rates ratios (1%, 3%, 5%). According to the toxicity test performed on zebrafish juveniles; GA-PEG-Epox (1%) constructs are non-toxic to zebrafish juveniles. The mortality rate of GA-PEG-Epox (3%) and GA-PEG-Epox (5%) structures was observed as 12.5% and 20.8%, respectively. It was observed that the structures were not toxic to zebrafish juveniles. MTT test performed on L929 fibroblast cells, high cell viability (>90%) was observed in all synthesized structures. These results are evaluated as Grade 1 according to ISO standards.en_US
dc.identifier.doi10.17776/csj.1385443
dc.identifier.endpage63en_US
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue1en_US
dc.identifier.startpage54en_US
dc.identifier.trdizinid1230141en_US
dc.identifier.urihttps://doi.org/10.17776/csj.1385443
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1230141
dc.identifier.urihttps://hdl.handle.net/11616/88782
dc.identifier.volume45en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofCumhuriyet Science Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSynthesis of Gum Arabic-Based Biopolymer Network and Determination of Its Toxicity Properties in In Vitro - In Vivo Model Systemsen_US
dc.typeArticleen_US

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