Protective Effects of Molsidomine Against Cisplatin-Induced Nephrotoxicity

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridyoldas, zeynep rumeysa/0000-0002-5608-9003
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidaltintas, ramazan/AAP-2348-2020
dc.contributor.authorKarakoc, Habib T. E.
dc.contributor.authorAltintas, Ramazan
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Alaaddin
dc.contributor.authorSamdanci, Emine
dc.contributor.authorSagir, Mustafa
dc.contributor.authorDuran, Zeynep R.
dc.date.accessioned2024-08-04T20:44:33Z
dc.date.available2024-08-04T20:44:33Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Cisplatin, an effective chemotherapeutic agent, is used for the treatment of several types of cancers. However, cisplatin has some severe side effects such as nephrotoxicity. On the other hand, molsidomine, a NO donor, has anti-oxidative and vasodilator effects. Objectives. The aim of this study was to estimate the protective effects of molsidomine on cisplatin-induced nephrotoxicity. Material and Methods. Thirty-two rats were randomly divided into 4 groups as follows: (1) control; (2) received a single-dose intraperitoneal (i.p.) injection of 5 mg/kg cisplatin; (3) received single i.p. dose of molsidomine (4 mg/kg/day) for 3 consecutive days before cisplatin treatment; (4) received single i.p. dose of molsidomine (4 mg/kg/day) for 3 consecutive days. The specific biochemical markers, including antioxidants, and the histopathological alterations were evaluated. Results. Cisplatin significantly increased malondialdehyde (MDA) and myeloperoxidase (MPO) levels and decreased glutathione peroxidase (GPX) level. Molsidomine significantly decreased MPO level nearly to control level; however, its ameliorating effects on MDA, SOD, CAT and GPX did not reach to significant levels. Cisplatin-induced elevation of blood-urea-nitrogen and serum-creatinine were diminished after molsidomine administration. Cisplatin also induced severe tubular degeneration, nuclear condensation, apoptosis and scattered patchy inflammation in the histological examination. Molsidomine improved all of these histological damages. Conclusions. In this study, the beneficial effect of molsidomine against cisplatin nephrotoxicity has been evaluated for the first time.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [2209/A-2012]en_US
dc.description.sponsorshipThis study was supported by a grant from The Scientific and Technological Research Council of Turkey (project No. 2209/A-2012, belongs to Mr. Karakoc).en_US
dc.identifier.doi10.17219/acem/58970
dc.identifier.endpage593en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue4en_US
dc.identifier.pmid26469102en_US
dc.identifier.scopus2-s2.0-85047289473en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage585en_US
dc.identifier.urihttps://doi.org/10.17219/acem/58970
dc.identifier.urihttps://hdl.handle.net/11616/98296
dc.identifier.volume24en_US
dc.identifier.wosWOS:000360287300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcisplatinen_US
dc.subjectmolsidomineen_US
dc.subjectkidneyen_US
dc.subjectraten_US
dc.titleProtective Effects of Molsidomine Against Cisplatin-Induced Nephrotoxicityen_US
dc.typeArticleen_US

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