Alpha-fetoprotein and albumin inversely relate to each other and to tumor parameters in patients with hepatocellular carcinoma

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dc.contributor.authorCarr, Brian
dc.contributor.authorGuerra, Vito
dc.contributor.authorInce, Volkan
dc.contributor.authorIsik, Burak
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:55:02Z
dc.date.available2024-08-04T20:55:02Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aim: Alpha-fetoprotein (AFP), an oncofetal protein and biomarker in hepatocellular carcinoma (HCC), has unclear roles and ac-tions.To evaluate the relationships between AFP, liver function tests, and HCC aggressiveness. Materials and Methods: A retrospective analysis of an HCC patient data-base was conducted to examine the relationships between baseline serum AFP values, liver function tests, and tumor characteristics. Results: Statistically significant positive trends were observed between AFP levels and both AST and bilirubin, along with negative trends between AFP and albumin. Significant correlations were also found between AFP and MTD, multifocality, and PVT. Increases in MTD, multifocality, and PVT were noted even at low AFP levels, indicating both AFP-independent and AFP-dependent processes. However, these parameter changes were minimal compared to the substantial changes in AFP levels. Relationships between AFP-related liver and tumor characteristics were found to be sim-ilar but inverse to those for albumin, with normal albumin levels associated with more favorable tumor characteristics. Additionally, serum levels of albumin and AFP were inversely related. Conclusion: AFP and albumin levels significantly, but inversely, correlate with tumor parameters, suggesting that albumin may suppress HCC func-tions and could serve as a potential prognostic marker.en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipFinancial Disclosure: This work was supported in part by NIH grant CA 82723 (B.I.C) .en_US
dc.identifier.doi10.14744/hf.2023.2023.0023
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue1en_US
dc.identifier.pmid38283277en_US
dc.identifier.scopus2-s2.0-85183899816en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.14744/hf.2023.2023.0023
dc.identifier.urihttps://hdl.handle.net/11616/101793
dc.identifier.volume5en_US
dc.identifier.wosWOS:001163820300011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofHepatology Forumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAFPen_US
dc.subjectHCCen_US
dc.subjectPVTen_US
dc.subjecttumor sizeen_US
dc.titleAlpha-fetoprotein and albumin inversely relate to each other and to tumor parameters in patients with hepatocellular carcinomaen_US
dc.typeArticleen_US

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