N-alkylbenzimidazole silver(I) complexes: Synthesis, biological evaluation and molecular docking study

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dc.authoridÜstün, Elvan/0000-0002-0587-7261
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridKarci, Huseyin/0000-0002-5709-1623
dc.authoridDundar, Muhammed/0000-0001-6509-2012
dc.authorwosidÜstün, Elvan/HJB-1157-2022
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidKarci, Huseyin/AAC-3985-2022
dc.authorwosidDundar, Muhammed/AAN-1831-2020
dc.contributor.authorAri, Erkan
dc.contributor.authorSahin, Neslihan
dc.contributor.authorUstun, Elvan
dc.contributor.authorDundar, Muhammed
dc.contributor.authorKarci, Huseyin
dc.contributor.authorOzdemir, Lknur
dc.contributor.authorKoc, Ahmet
dc.date.accessioned2024-08-04T20:54:55Z
dc.date.available2024-08-04T20:54:55Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of N-alkylbenzimidazole silver(I) complexes were synthesized and fully characterized by FT-IR, Mass, 1H, 13C{1H} NMR spectroscopy, and elemental analysis. Synthesized N-alkylbenzimidazole silver(I) complexes were investigated for their antimicrobial activities against bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and the fungal strains Candida albicans and Candida glabrata. All the complexes (2a-f) showed higher antimicrobial activity against bacteria than fungi strains. In particular, complexes 2b and 2e showed comparable activity to Ampicillin against Escherichia coli. Also, all complexes showed better activity than Ampicillin against Pseudomonas aeruginosa. The complex 2e showed remarkable activity against Candida albicans (12.5 mu g/mL) and Candida glabrata (25 mu g/mL). The molecules that were first optimized by DFT-based calculation methods were also analyzed by molecular docking methods against DNA gyrase of E. Coli, CYP51 from Candida glabrata, and Penicillin Binding Protein-3.en_US
dc.description.sponsorshipInonu University Research Fund [FBG-2021-2562]en_US
dc.description.sponsorshipThis work was financially supported by the Inonu University Research Fund (FBG-2021-2562).en_US
dc.identifier.doi10.1016/j.poly.2023.116758
dc.identifier.issn0277-5387
dc.identifier.issn1873-3719
dc.identifier.scopus2-s2.0-85178497751en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2023.116758
dc.identifier.urihttps://hdl.handle.net/11616/101699
dc.identifier.volume248en_US
dc.identifier.wosWOS:001134916600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalkyl benzimidazoleen_US
dc.subjectSilveren_US
dc.subjectAntimicrobial activityen_US
dc.subjectMolecular dockingen_US
dc.titleN-alkylbenzimidazole silver(I) complexes: Synthesis, biological evaluation and molecular docking studyen_US
dc.typeArticleen_US

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