Is 24,25(OH)D level really high in dialysis patients with high FGF23 levels?

Basit Öğe Kaydı
dc.authoridtaskapan, hulya/0000-0001-8736-4779
dc.authorwosidtaskapan, hulya/ABI-7737-2020
dc.contributor.authorTaskapan, Hulya
dc.date.accessioned2024-08-04T20:36:11Z
dc.date.available2024-08-04T20:36:11Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDeficiency of 1,25-dihydroxyvitamin D [1,25(OH)(2)D] and excessive fibroblast growth factor (FGF23) are suggested to be associated with increased mortality in patients with chronic kidney disease (CKD). Generally, 24-hydroxylation has been considered the first step in the degradation pathway of 1,25(OH)(2)D and 25(OH)D. 24,25-dihydroxyvitamin D [24,25(OH)(2)D] was believed to be a degradation product, with no important biological effects. However, some data have accumulated showing that 24,25(OH)(2)D has biological effects on its own. Under conditions of eucalcemia, the synthesis of 24,25(OH)(2)D is increased, and the synthesis of 1,25(OH)(2)D is decreased. In patients with CKD, both high parathyroid hormone levels, which decrease the activity of enzyme CYP24A1 (24-hydroxylase), and high FGF23 levels, which increase the activity of enzyme CYP24A1, were often detected. However, information about 24,25(OH)(2)D levels in these patients is very limited. Whether compensatory changes in levels of FGF23 and 24,25(OH)(2)D in CKD patients are protective or harmful remain unknown issues. Therefore, more studies are needed to identify the nature of the interactions between these molecules and to fully elucidate their clinical significance.en_US
dc.identifier.doi10.1007/s11255-012-0157-5
dc.identifier.endpage1144en_US
dc.identifier.issn0301-1623
dc.identifier.issue4en_US
dc.identifier.pmid22467088en_US
dc.identifier.scopus2-s2.0-84867896920en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1135en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-012-0157-5
dc.identifier.urihttps://hdl.handle.net/11616/95828
dc.identifier.volume44en_US
dc.identifier.wosWOS:000306683200023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,25(OH)(2)Den_US
dc.subject24,25(OH)(2)Den_US
dc.subjectCYP24A1en_US
dc.subjectFibroblast growth factor 23en_US
dc.titleIs 24,25(OH)D level really high in dialysis patients with high FGF23 levels?en_US
dc.typeReview Articleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu