Comparison of Dissolution Profiles of Commercially Available Lamivudine Tablets

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dc.authoridKAYNAK, Mustafa Sinan/0000-0003-2917-2407
dc.authoridOzturk, Naile/0000-0002-7617-8433
dc.authorwosidKAYNAK, Mustafa Sinan/D-9453-2019
dc.authorwosidOzturk, Naile/F-3650-2017
dc.contributor.authorOzturk, Naile
dc.contributor.authorKaynak, Mustafa Sinan
dc.contributor.authorSahin, Selma
dc.date.accessioned2024-08-04T20:41:19Z
dc.date.available2024-08-04T20:41:19Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the influence of dissolution medium on the in vitro release of lamivudine (100 mg) from four commercially available lamivudine tablets (one reference and three generic). Three different buffer solutions (pH 1.2, 4.5, 6.8) and deaerated water were used as the dissolution media (900 mL), and the paddle rotation speed was kept at 50 rpm with twelve replicates. An RP HPLC method was developed for analysis of lamivudine in samples obtained from dissolution studies. The mobile phase consisted of acetonitrile/water (10:90) pH adjusted to pH 2.5 with o-phosphoric acid, a C-18 column (Ace 250 x 4.60 mm, 5 mu m) was used, and the flow rate was set at 1 mL/min. All the drugs tested were very rapidly dissolving (more than 85% of the labeled amount in 15 min), and the dissolution profiles of the generic tablets were thus considered similar to that of the reference tablet in each of the buffers at pH 1.2, 4.5, and 6.8, and deaerated water. Because of the dissolution results and the high solubility and borderline permeability, a biowaiver can be proposed for lamivudine immediate-release solid oral dosage forms provided that the excipient composition of the test product is the same as or similar to that of the reference product and the excipients that have an effect on bioavailability are qualitatively and quantitatively the same as that of the reference product.en_US
dc.identifier.doi10.14227/DT220415P38
dc.identifier.endpage43en_US
dc.identifier.issn1521-298X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84947903403en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.14227/DT220415P38
dc.identifier.urihttps://hdl.handle.net/11616/97062
dc.identifier.volume22en_US
dc.identifier.wosWOS:000366616100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDissolution Technologies, Incen_US
dc.relation.ispartofDissolution Technologiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLamivudineen_US
dc.subjectdissolution profileen_US
dc.subjectbiowaiveren_US
dc.subjectdissolutionen_US
dc.titleComparison of Dissolution Profiles of Commercially Available Lamivudine Tabletsen_US
dc.typeArticleen_US

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