Is eribulin treatment prognostic factor in patients with metastatic breast cancer treated with this drug? Retrospective analysis of a multicentre study
dc.authorscopusid | 56609149600 | |
dc.authorscopusid | 55504930000 | |
dc.authorscopusid | 55189913500 | |
dc.authorscopusid | 57211790367 | |
dc.authorscopusid | 55402747600 | |
dc.authorscopusid | 56890954100 | |
dc.authorscopusid | 6505910645 | |
dc.contributor.author | Oruc Z. | |
dc.contributor.author | Kaplan M.A. | |
dc.contributor.author | Geredeli C. | |
dc.contributor.author | Sari N.Y. | |
dc.contributor.author | Ozaslan E. | |
dc.contributor.author | Aytekin A. | |
dc.contributor.author | Elkiran E.T. | |
dc.date.accessioned | 2024-08-04T20:00:47Z | |
dc.date.available | 2024-08-04T20:00:47Z | |
dc.date.issued | 2019 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | Purpose: This study aimed to analyze prognostic factors for survival and the reliability and the effectiveness of eribulin therapy in metastatic breast cancer (MBC) patients. Methods: A total of 80 patients treated with eribulin in 12 medical oncology centers in Turkey between 2013-2017 were retrospectively evaluated. Sixteen potential prognostic variables were assessed for analysis. Results: The patients had received a median of 5 prior chemotherapy regimens and a median of 3 eribulin cycles for MBC. Median progression-free survival (PFS) was 5.5 months (95% Cl: 4.1-7.8) and median overall survival (OS) was 11 months (95 % Cl: 6-15). Multivariate analysis showed that eribulin treatment line was shown to have independent prognostic significance for PFS. PFS difference was demostrated in patients who received 3 chemotherapy lines for advanced disease compared to those who had more than 3 chemotherapy lines [median PFS; 3 lines: 8.6 months (6.2-11) and >3 lines: 4.6 months (3.7-4.6) p=0.00]. The clinical benefit rate (CBR) was 52.5 and 35% in patients treated with three lines and with >3 previous chemotherapeutic regimens. Most common toxicities were neutropenia (62.5%), fatigue (52.5%), alopecia (50%) and nausea (37.5%). Conclusions: Eribulin treatment line was identified as in-depedent prognostic factor for PFS in MBC patients. © 2019 Zerbinis Publications. All rights reserved. | en_US |
dc.identifier.endpage | 1883 | en_US |
dc.identifier.issn | 1107-0625 | |
dc.identifier.issue | 5 | en_US |
dc.identifier.pmid | 31786850 | en_US |
dc.identifier.scopus | 2-s2.0-85075002263 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 1876 | en_US |
dc.identifier.uri | https://hdl.handle.net/11616/91006 | |
dc.identifier.volume | 24 | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Zerbinis Publications | en_US |
dc.relation.ispartof | Journal of B.U.ON. | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Chemotherapy | en_US |
dc.subject | Eribulin | en_US |
dc.subject | Metastatic breast cancer | en_US |
dc.subject | Prognostic factors | en_US |
dc.title | Is eribulin treatment prognostic factor in patients with metastatic breast cancer treated with this drug? Retrospective analysis of a multicentre study | en_US |
dc.type | Article | en_US |