Elevated plasma homocysteine levels in patients with isolated coronary artery ectasia

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dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.authorwosidaksoy, yüksel/ABH-1304-2021
dc.authorwosidsincer, isa/Y-6513-2018
dc.contributor.authorKosar, F
dc.contributor.authorSincer, I
dc.contributor.authorAksoy, Y
dc.contributor.authorOzerol, I
dc.date.accessioned2024-08-04T20:15:27Z
dc.date.available2024-08-04T20:15:27Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Coronary artery ectasia is a variant of coronary atherosclerosis. Hyperhomocysteinemia has emerged as a major, independent risk factor for cardiovascular diseases. The purposes of this study were to determine plasma hyperhomocysteine levels in patients with coronary artery ectasia, and to compare patients with coronary artery ectasia, coronary artery disease, and controls with normal coronary angiogram. Method The study population included 37 patients with coronary artery ectasia and 36 patients with coronary artery disease. The control group consisted of 32 patients with angiographically proven normal coronary arteries. Plasma hyperhomocysteine levels were measured in all study patients with an enzyme-linked immunosorbent assay. Results Plasma homocysteine levels were significantly higher in patients with both coronary artery ectasia and coronary artery disease than in the controls (14.8 +/- 1.1 and 15.9 +/- 0.8 vs. 2.5 +/- 0.6 mu mol/l; P < 0.001 and P < 0.001, respectively). No significant differences in plasma homocysteine levels were found among CAE and CAD groups (P > 0.05). Conclusions We have demonstrated that patients with coronary artery ectasia and coronary artery disease have increased plasma hyperhomocysteine levels compared with the controls. These findings suggest that hyperhomocysteinemia may play an important role in the pathogenesis of coronary artery ectasia as in coronary artery disease.en_US
dc.identifier.doi10.1097/00019501-200602000-00004
dc.identifier.endpage27en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue1en_US
dc.identifier.pmid16374137en_US
dc.identifier.scopus2-s2.0-33646980201en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1097/00019501-200602000-00004
dc.identifier.urihttps://hdl.handle.net/11616/94393
dc.identifier.volume17en_US
dc.identifier.wosWOS:000234323900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectcoronary artery ectasiaen_US
dc.subjecthomocysteineen_US
dc.titleElevated plasma homocysteine levels in patients with isolated coronary artery ectasiaen_US
dc.typeArticleen_US

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