Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease

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dc.authoridAral, Kubra/0000-0003-4798-4548
dc.authorwosidAral, Kubra/R-3039-2017
dc.contributor.authorKirmiziguel, Omer Alperen
dc.contributor.authorSabanci, Arife
dc.contributor.authorDisli, Faruk
dc.contributor.authorYildiz, Sedat
dc.contributor.authorMilward, Michael R.
dc.contributor.authorAral, Kubra
dc.date.accessioned2024-08-04T20:54:32Z
dc.date.available2024-08-04T20:54:32Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundMitochondria and endoplasmic reticulum are key cellular organelles and create contact sites (mitochondria-endoplasmic reticulum contact [MERC]), which plays a major role in calcium metabolism, apoptotic processes, and inflammation. Previously, proteins that have been associated with these MERC contact sites mitofusin-1 (MFN1) and mitofusin-2 (MFN2) have been found to be downregulated in periodontal disease in vitro. Therefore, the aim of the current study was to evaluate MFN1 and MFN2 in gingival crevicular fluid (GCF) of patients with periodontal disease compared with healthy controls clinically. MethodsA total of 48 participants were divided into three groups including periodontally healthy (n = 16), patients with gingivitis (n = 16), and patients with stage 3 grade B periodontitis (n = 16). GCF levels of MFN1, MFN2, calcium (Ca), caspase-1, and tumor necrosis factor-alpha (TNF-& alpha;) were determined via enzyme-linked immunosorbent assay (ELISA). Results were calculated as total amount and concentration. ResultsMFN1 levels (total amount) were significantly higher in patients with periodontitis and gingivitis when compared with healthy controls (p < 0.05). However, concentration levels of MFN1, MFN2, Ca, caspase-1, TNF-& alpha; significantly decreased in periodontal disease groups compared with healthy controls (p < 0.05). A positive correlation was detected among all evaluated markers (p < 0.05). ConclusionThe MERC protein MFN1 may have a role in the pathogenesis of periodontal disease due to its increase in GCF of patients with periodontitis and gingivitis.en_US
dc.description.sponsorshipInonu University, Malatya, Turkiye Research Fund [TSA-2022-2754]en_US
dc.description.sponsorshipThis study was supported by Inonu University, Malatya, Turkiye Research Fund Grant TSA-2022-2754. The authors report no conflicts of interest related to this study.en_US
dc.identifier.doi10.1002/JPER.23-0072
dc.identifier.endpage73en_US
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue1en_US
dc.identifier.pmid37436713en_US
dc.identifier.scopus2-s2.0-85165587576en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://doi.org/10.1002/JPER.23-0072
dc.identifier.urihttps://hdl.handle.net/11616/101483
dc.identifier.volume95en_US
dc.identifier.wosWOS:001034071700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcalciumen_US
dc.subjectcaspase 1en_US
dc.subjectMFN1en_US
dc.subjectmitochondriaen_US
dc.subjectperiodontitisen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.titleEvaluation of the role of mitofusin-1 and mitofusin-2 in periodontal diseaseen_US
dc.typeArticleen_US

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