Protective role of caffeic acid phenethyl ester in the liver of rats exposed to cold stress

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridYılmaz, İsmet/0000-0002-7204-1050;
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidERDOĞAN, Ali/ABG-8548-2020
dc.contributor.authorAtes, B
dc.contributor.authorDogru, MI
dc.contributor.authorGul, M
dc.contributor.authorErdogan, A
dc.contributor.authorDogru, AK
dc.contributor.authorYilmaz, I
dc.contributor.authorYurekli, M
dc.date.accessioned2024-08-04T20:15:25Z
dc.date.available2024-08-04T20:15:25Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCold exposure can induce a form of environmental stress. Cold stress (CS) alters homeostasis, results in the creation of reactive oxygen species and leads to alterations in the antioxidant defense system. The caffeic acid phenethyl ester (CAPE), an active component of propolis, has an antioxidant capacity. We investigated the effect of CS on oxidative stress and antioxidant defense system and the possible protective effect of CAPE in rat liver tissue. Twenty-four female Wistar Albino rats were divided into four groups: Control, CAPE-treated, CS, and CAPE-treated CS (CS + CAPE) group. Catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) activities and total glutathione (GSH) and malondialdehyde (MDA) levels were measured. In addition, histological changes in liver tissue were examined by light microscopy. SOD, CAT and GSH-Px activities and total GSH level were significantly declined in the CS group. In the CS + CAPE group, the activities of these three enzymes and GSH level significantly raised with regard to the CS group. MDA levels increased in the CS group and decreased in the CS + CAPE group. The tissues of the CS group showed some histopathological changes such as necrosis, hepatocyte degeneration, sinusoidal dilatation, hemorrhage and vascular congestion and dilatation. In the CS + CAPE group, the histopathological evidence of hepatic damage was markedly reduced. Histological parameters were consistent with biochemical parameters. In this study, CS increased oxidative stress in liver tissue. CAPE regulated antioxidant enzymes, inhibited lipid peroxidation and reduced hepatic damage.en_US
dc.identifier.doi10.1111/j.1472-8206.2006.00402.x
dc.identifier.endpage289en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue3en_US
dc.identifier.pmid16671963en_US
dc.identifier.scopus2-s2.0-33646522910en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.1111/j.1472-8206.2006.00402.x
dc.identifier.urihttps://hdl.handle.net/11616/94378
dc.identifier.volume20en_US
dc.identifier.wosWOS:000237300600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidant enzymesen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectcold stressen_US
dc.subjecthistological parametersen_US
dc.subjectlipid peroxidationen_US
dc.subjectoxidative stressen_US
dc.titleProtective role of caffeic acid phenethyl ester in the liver of rats exposed to cold stressen_US
dc.typeArticleen_US

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