Glucose-insulin-potassium solution before cardiopulmonary bypass in coronary artery surgery

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dc.authorscopusid6603931556
dc.authorscopusid55666804700
dc.authorscopusid57213086727
dc.authorscopusid7006384185
dc.authorscopusid34569135700
dc.authorscopusid6601993488
dc.authorscopusid7004486274
dc.contributor.authorTurkoz A.
dc.contributor.authorToprak H.I.
dc.contributor.authorSari S.
dc.contributor.authorOzturk E.
dc.contributor.authorDurmus M.
dc.contributor.authorTurkoz R.
dc.contributor.authorErsoy M.O.
dc.date.accessioned2024-08-04T20:00:36Z
dc.date.available2024-08-04T20:00:36Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractGlucose-insulin-potassium (GIK) solution has been advocated for the treatment of ischemic myocardium. This prospective, randomized clinical study was conducted to evaluate whether GIK solutions would cause benefit for the patients in addition to anterograd and retrograd combined blood cardioplegia undergoing coronary artery bypass grafting because of depressed left ventricle and unstable angina. The study group consisted of 33 patients with depressed left ventricle and unstable angina who underwent coronary artery bypass grafting, 2 patients were excluded from the study because of catheter dislocation. In 15 patients GIK solution (500 mL of 30 % dextrose, 70 units insuline, 80 mEq potassium) was given intravenously at 1 mL/kg per hour started with induction of anaesthesia, until the stage of cardiopulmonary bypass (CPB). Sixteen patients received ringer's lactate as the control group. The patients were analysed for hemodynamic changes, blood glucose and potassium levels. Pulmonary capillary wedge pressure, cardiac output, systemic vascular resistance, pulmonary vascular resistance were not different between two groups immediately before and after CPB. Blood glucose levels were not different between the two groups, but in both groups the levels increased after the end of the infusion of GIK solution, on the fifteenth minutes and at the end of the CPB. No differences were determined at the end of operation. There was no difference in serum potassium levels between the two groups, but potassium levels increased significantly during and immediately after CPB and decreased to the basal levels at the end of the operation in both groups. There was no significant difference between the groups in perioperative myocardial infarction, incidence of atrial and ventricular arrhythmias, times of ventilator support, length of stay in the intensive care unit and mortality. In this study, GIK therapy did not produce any additional positive hemodynamic effects and postoperative recovery from depressed left ventricle and urgent coronary artery bypass grafting.en_US
dc.identifier.endpage365en_US
dc.identifier.issn1016-5150
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-0033784354en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage361en_US
dc.identifier.urihttps://hdl.handle.net/11616/90845
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary artery bypass graftingen_US
dc.subjectGlucoseen_US
dc.subjectInsulinen_US
dc.subjectPotassiumen_US
dc.titleGlucose-insulin-potassium solution before cardiopulmonary bypass in coronary artery surgeryen_US
dc.title.alternativeKoroner arter cerrahisinde kardiyopulmoner bypass oncesi glukoz-insulin-potasyum solusyonuen_US
dc.typeArticleen_US

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