Determination of copper, zinc and manganese in nail and serum from patients with migraine

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dc.authoridIlhan, Nevin/0000-0002-0208-8929
dc.authoridİLHAN, NECİP/0000-0001-9997-0418;
dc.authorwosidIlhan, Nevin/J-5761-2017
dc.authorwosidİLHAN, NECİP/V-8908-2018
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.contributor.authorÖzerol, E
dc.contributor.authorUlvi, H
dc.contributor.authorIlhan, N
dc.contributor.authorGüleç, M
dc.contributor.authorIlhan, A
dc.contributor.authorAkyol, Ö
dc.date.accessioned2024-08-04T20:13:28Z
dc.date.available2024-08-04T20:13:28Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description2nd International Meeting on Free Radicals in Health and Disease -- MAY 08-12, 2002 -- ISTANBUL, TURKEYen_US
dc.description.abstractMetallo-enzymes contain trace elements in their molecular structure to be metabolically active. Manganese-superoxide dismutase (Mn SOD) contains Mn and copper, zinc-superoxide dismutase (Cu, Zn SOD) contains Cu. and Zn as prosthetic groups. There have been some studies on the oxidant/anti oxidant status of patients with migraine. In the present study, the levels of copper, zinc and manganese in nail and serum were investigated in 53 patients with migraine and 19 healthy subjects. Copper, Zn and Mn levels were measured by atomic absorption spectrophotometry and results obtained were statistically compared. The concentration of Mn in nail and serum was significantly higher in migraine patients than those of control subjects. Although Zn and Cu concentrations in nail were increased in migraine group compared to control group, the difference was not statistically significant. There was a statistically significant increase in Cu level (p < 0.02) and decrease in Zn level in serum from patients with migraine compared to those of control group. The unchanged or increased levels of trace elements, which play important roles as prosthetic groups in SOD, in both nail and serum may suggest that the antioxidant enzyme activities are not negatively affected from the changes. The results obtained are discussed in the light of the literature on the relationship between migraine and trace elements plus antioxidant systems.en_US
dc.identifier.endpage233en_US
dc.identifier.issn0174-7371
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0141995809en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage230en_US
dc.identifier.urihttps://hdl.handle.net/11616/93636
dc.identifier.volume20en_US
dc.identifier.wosWOS:000186034300006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofTrace Elements and Electrolytesen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcopperen_US
dc.subjectmanganeseen_US
dc.subjectmigraineen_US
dc.subjectnailen_US
dc.subjectserumen_US
dc.subjectzincen_US
dc.titleDetermination of copper, zinc and manganese in nail and serum from patients with migraineen_US
dc.typeConference Objecten_US

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