Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats

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dc.authoridGul, Huseyin Fatih/0000-0002-9828-1298
dc.authoridBircan, Burak/0000-0003-1141-069X
dc.authoridBircan, Burak/0000-0003-1141-069X
dc.authoridCakir, Murat/0000-0002-2066-829X
dc.authorwosidGul, Huseyin Fatih/AAN-7673-2021
dc.authorwosidBircan, Burak/GYD-4516-2022
dc.authorwosidBircan, Burak/JWO-5732-2024
dc.authorwosidCakir, Murat/I-8643-2019
dc.contributor.authorBircan, Burak
dc.contributor.authorCakir, Murat
dc.contributor.authorKirbag, Sevda
dc.contributor.authorGul, Huseyin Fatih
dc.date.accessioned2024-08-04T20:42:33Z
dc.date.available2024-08-04T20:42:33Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractApelin is a peptide hormone defined as a ligand for G-protein clamped receptor (APJ) receptor. It is indicated in the literature both apelin and APJ are synthesized on the peripheral tissues including the renal tissues. Which roles does the apelin play on the renal tissue has not been completely illuminated yet. This study is designed to determine the possible protective effect of apelin-13 on the kidney I/R injury. Adult male Sprague-Dawley rats were used in this study. In the sham group, right kidneys of the animals were dissected. In the I/R group, right kidney was dissected and ischemia of 45min was performed, and then reperfusion was applied for 3h. In the treatment groups, three different doses of apelin were injected at the beginning of the ischemia unlike the I/R group. BUN, Cre, Na, K, Cl, total protein and albumin from serum samples were determined and TNF-, IL-1, IL-6, TAS and TOS parameters were read with ELISA reader. MDA, SOD, CAT and GSH-Px enzyme activations from renal tissues were measured. In comparison with the sham and I/R groups, while the serum BUN, CRE, CI and TNF- levels showed an increase in the groups on which the apelin-13 was applied, Na, total protein, albumin, TAS levels decreased. Serum TOS level of other groups showed an increase by comparison with the sham group. Our results showed that apelin-13 applied after I/R increased the antioxidant enzyme activity in a dose dependent manner, prevented the lipid oxidation and improved the renal functions.en_US
dc.description.sponsorshipFirat University Department of Scientific Research Projects [FF.13.20]en_US
dc.description.sponsorshipThis study was supported by Firat University Department of Scientific Research Projects (Project no: FF.13.20).en_US
dc.identifier.doi10.1080/0886022X.2016.1184957
dc.identifier.endpage1128en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7en_US
dc.identifier.pmid27197832en_US
dc.identifier.scopus2-s2.0-84979529668en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1122en_US
dc.identifier.urihttps://doi.org/10.1080/0886022X.2016.1184957
dc.identifier.urihttps://hdl.handle.net/11616/97442
dc.identifier.volume38en_US
dc.identifier.wosWOS:000382175000015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectapelinen_US
dc.subjectAPJen_US
dc.subjectischemia-reperfusionen_US
dc.subjectkidneyen_US
dc.subjectoxidative stressen_US
dc.titleEffect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in ratsen_US
dc.typeArticleen_US

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