Role of Propolis on Tyrosine Hydroxylase Activity and Blood Pressure in Nitric Oxide Synthase-Inhibited Hypertensive Rats

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dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.contributor.authorGogebakan, Ayse
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorSahna, Engin
dc.date.accessioned2024-08-04T20:36:10Z
dc.date.available2024-08-04T20:36:10Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractReduction in the synthesis or bioavailability of nitric oxide plays a significant role in the development of hypertension. Propolis is a resinous product collected by honeybees from various plant sources. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines. The aim of this study was to examine the effect of propolis on blood pressure (BP), TH, and total RNA levels in the adrenal medulla, heart, and hypothalamus tissues in chronic nitric oxide synthase (NOS)-inhibited rats by N-w-nitro-L-arginine methyl ester (L-NAME). Rats received NOS inhibitor (L-NAME) for 15 days to produce hypertension and propolis for the last 5 days. TH activity and total RNA levels significantly increased in adrenal medulla, heart, and hypothalamus tissues in L-NAME-treated groups (P < .05). TH activity and total RNA levels of L-NAME+propolis-treated rats reduced (P < .05) compared with L-NAME-treated groups. TH activity in propolis-treated rats was reduced to the control values. L-NAME led to a significant increase in BP compared with the control group. Propolis administration to L-NAME-treated rats reduced BP but this was not statistically significant compared to L-NAME-treated groups. These results suggest that propolis decreases TH activity in NOS-inhibited hypertensive rats and thereby may modulate the synthesis of catecholamine and BP.en_US
dc.description.sponsorshipNigde University [BAP 2008/25]en_US
dc.description.sponsorshipThe Nigde University Research Fund (BAP 2008/25) is gratefully acknowledged for supporting this work. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.en_US
dc.identifier.doi10.3109/10641963.2012.665542
dc.identifier.endpage428en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue6en_US
dc.identifier.pmid22471835en_US
dc.identifier.scopus2-s2.0-84866103517en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage424en_US
dc.identifier.urihttps://doi.org/10.3109/10641963.2012.665542
dc.identifier.urihttps://hdl.handle.net/11616/95797
dc.identifier.volume34en_US
dc.identifier.wosWOS:000308422300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofClinical and Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttyrosine hydroxylaseen_US
dc.subjectL-NAMEen_US
dc.subjectnitric oxideen_US
dc.subjectblood pressureen_US
dc.subjectpropolisen_US
dc.subjectraten_US
dc.titleRole of Propolis on Tyrosine Hydroxylase Activity and Blood Pressure in Nitric Oxide Synthase-Inhibited Hypertensive Ratsen_US
dc.typeArticleen_US

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