The protective effects of apocynin on ionizing radiation induced intestinal damage in rats

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dc.authoridTR102000en_US
dc.authoridTR100549en_US
dc.authoridTR45132en_US
dc.authoridTR116272en_US
dc.authoridTR58662en_US
dc.authoridTR57487en_US
dc.contributor.authorÇağın, Yasir Furkan
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardı, Nigar
dc.contributor.authorAtayan, Yahya
dc.contributor.authorErdoğan, Mehmet Ali
dc.contributor.authorYıldız, Azibe
dc.contributor.authorSarıhan, Mehmet Ediz
dc.contributor.authorAladağ, H.
dc.date.accessioned2017-04-11T10:34:02Z
dc.date.available2017-04-11T10:34:02Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and aims: Radiation colitis typically emerges during radiotherapy of intraabdominal malignancies. While the underlying mechanism remains unclear, it is considered that free oxygen radicals act like cellular mediators to cause colonic damage. Apocynin (APO) prevents oxidative stress and apoptotic cell death by inhibiting NADPH oxidase, and preventing the formation of free oxygen radicals. The aim of the present study was to investigate the protective effect of APO, a strong antioxidant and antiinflammatory agent, on radiation induced colonic oxidative damage in rats. Materials and methods: Rats were randomly divided into four groups (n ¼ 8/group). Group I (control group); Group II (Group RAD) received a single dose of 800 cGy ionizing radiation to the whole abdomen with a linear accelerator (LINAC); Group III (Group APO) received a single dose of 20 mg/kg of APO intraperitoneally for five days; Group IV (Group APO+RAD) received APO for five days before radiation exposure (similar to Group III), (similar to Group II). Results: APO treatment prior to radiation led to protection in the biochemical and histopathological parameters. Conclusions: Our study shows that APO treatment before radiation improves radiation induced colonic injury in rats, by decreasing oxidative stress and apoptosis.en_US
dc.identifier.citationÇağın, Y. F. Parlakpınar, H. Polat, A. Vardı, N. Atayan, Y. Erdoğan, M. A. Yıldız, A. Sarıhan, M. E. Aladağ, H. The protective effects of apocynin on ionizing radiation induced intestinal damage in rats, Drug Development and Industrial Pharmacy, 317-324.en_US
dc.identifier.doi10.3109/03639045.2015.1052080en_US
dc.identifier.endpage324en_US
dc.identifier.issn0363-9045
dc.identifier.issue2en_US
dc.identifier.startpage317en_US
dc.identifier.urihttp://dx.doi.org/10.3109/03639045.2015.1052080
dc.identifier.urihttps://hdl.handle.net/11616/6631
dc.identifier.volume42en_US
dc.language.isoenen_US
dc.publisherDrug development and industrial pharmacyen_US
dc.relation.ispartofDrug development and industrial pharmacyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApocyninen_US
dc.subjectIntestine damageen_US
dc.subjectOxidative stressen_US
dc.subjectRadiationen_US
dc.subjectRaten_US
dc.titleThe protective effects of apocynin on ionizing radiation induced intestinal damage in ratsen_US
dc.typeArticleen_US

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