Effects of Oral ?- Glucan on Liver Ischemia/Reperfusion Injury in Rats

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dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authorwosidErdogan, Mehmet Ali/ABI-7224-2020
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.contributor.authorAydogan, M. S.
dc.contributor.authorYucel, A.
dc.contributor.authorErdogan, M. A.
dc.contributor.authorPolat, A.
dc.contributor.authorCetin, A.
dc.contributor.authorUcar, M.
dc.contributor.authorDuran, Z. R.
dc.date.accessioned2024-08-04T20:37:28Z
dc.date.available2024-08-04T20:37:28Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim. Ischemia/reperfusion (IR) injury (IRI) in liver transplant patients may negatively affect graft function. Although beta-glucan protects kidneys against IRI, its effect on the liver is unknown. This study sought to investigate beta-glucan effects on oxidative damage to the liver after IRI in rats. Materials and Methods. Thirty-two rats were randomly divided into 4 experimental groups n = 8 in each group: sham, IR, beta-glucan and IR + beta-glucan. beta-Glucan (50 mg kg(-1) . day(-1)) was orally administered for 10 days to rats in the beta-glucan and IR + beta-glucan groups. The rats in the IR and IR + beta-glucan groups were subjected to ischemia and reperfusion (IR) for 60 minutes each. All rats were killed on day 11 to evaluate histological changes as well as tissue levels of oxidants and antioxidants. Results. Malondialdehyde (MDA) levels were significantly higher in the IR than the sham group (P = .001). MDA level was significantly higher in the IR group than in the IR + beta-glucan group (P = .001). The levels of tissue antioxidant markers (superoxide dismutase [SOD], glutathione-peroxidase [GPx], and catalase [CAT]) were significantly lower in the IR group than in the sham group (P < .05). SOD and GPx levels did not differ significantly between the IR and IR + beta-glucan groups. CAT activity was significantly higher in the IR than the IR + beta-glucan group (P = .001). Histological tissue damage was reduced in the IR + beta-glucan than the IR group. Conclusion. Liver IRI is an inevitable problem during liver surgery. Our results suggested that beta-glucan pretreatment suppressed oxidative stress and increased antioxidant levels in an rat model of liver IRI.en_US
dc.identifier.doi10.1016/j.transproceed.2012.07.154
dc.identifier.endpage491en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue2en_US
dc.identifier.pmid23498783en_US
dc.identifier.scopus2-s2.0-84875191745en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage487en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2012.07.154
dc.identifier.urihttps://hdl.handle.net/11616/95987
dc.identifier.volume45en_US
dc.identifier.wosWOS:000316772500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectProtectsen_US
dc.subjectPreventionen_US
dc.subjectCatalaseen_US
dc.subjectDamageen_US
dc.titleEffects of Oral ?- Glucan on Liver Ischemia/Reperfusion Injury in Ratsen_US
dc.typeArticleen_US

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