The utility of lactate dehydrogenase isoenzyme pattern in the diagnostic evaluation of malignant and nonmalignant ascites

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dc.authoridSevinç, Alper/0000-0002-0499-8918
dc.authorwosidSari, Ramazan/C-2868-2016
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.contributor.authorSevinc, A
dc.contributor.authorSari, R
dc.contributor.authorFadillioglu, E
dc.date.accessioned2024-08-04T20:13:41Z
dc.date.available2024-08-04T20:13:41Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Lactate dehydrogenase (LDH), a tetrameric protein composed of four monomers, is expressed as five isoenzymes. Serum LDH isoenzymes may be useful in differential diagnosis of ascites etiology since tissue damage releases isoenzymes contained therein, leading to a change in their pattern. Materials and Methods: We determined ascitic fluid LDH level and LDH isoenzyme activities in patients with malignant and nonmalignant ascites in a total of 76 patients (43 males and 33 females). Results: LDH level, LDH-4 activity and LDH-5 activity were found to be significantly higher, and LDH-1 activity was found to be lower in malignant ascites when compared with nonmalignant ascites. LDH-1 activity was detected to be significantly higher in the sterile cirrhotic ascites when compared with spontaneous bacterial peritonitis, malignant ascites, tuberculous ascites and congestive heart failure-related ascites. LDH-2 activity was found to be higher in spontaneous bacterial peritonitis when compared with the other groups. LDH-3 activity was detected to be higher in spontaneous bacterial peritonitis, malignant ascites and tuberculous ascites when compared with the sterile cirrhotic ascites. In the diagnosis of malignant ascites, the sensitivity and specificity were 96% and 76% for LDH level, 90% and 70% for LDH-1 activity, 94% and 62% for LDH-4 activity, and 100% and 56% for LDH-5 activity, respectively. Conclusion: Ascitic LDH and its isoenzyme pattern may be helpful for the differential diagnosis of the most common causes of ascites: cirrhosis, spontaneous bacterial peritonitis, congestive heart failure, tuberculosis and malignancy.en_US
dc.identifier.endpage84en_US
dc.identifier.issn0027-9684
dc.identifier.issue1en_US
dc.identifier.pmid15719876en_US
dc.identifier.scopus2-s2.0-12344274314en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://hdl.handle.net/11616/93787
dc.identifier.volume97en_US
dc.identifier.wosWOS:000226343700011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatl Med Assocen_US
dc.relation.ispartofJournal of The National Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlactate dehydrogenaseen_US
dc.subjectisoenzymesen_US
dc.subjectascitic fluiden_US
dc.subjectmalignancyen_US
dc.titleThe utility of lactate dehydrogenase isoenzyme pattern in the diagnostic evaluation of malignant and nonmalignant ascitesen_US
dc.typeArticleen_US

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