Study of the neuroprotective effect of ginseng on superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels in experimental diffuse head trauma

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dc.authoridGÜDÜ, BURHAN/0000-0002-5011-815X
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridGül, Mehmet/0000-0002-1374-0783;
dc.authorwosidGÜDÜ, BURHAN/ABC-1595-2021
dc.authorwosidDoğan, Zümrüt/GQP-2535-2022
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.contributor.authorDemir, Ismail
dc.contributor.authorKiymaz, Nejmi
dc.contributor.authorGudu, Burhan Oral
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorGul, Mehmet
dc.contributor.authorDogan, Zumrut
dc.contributor.authorDemirtas, Sezin
dc.date.accessioned2024-08-04T20:37:53Z
dc.date.available2024-08-04T20:37:53Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of our study was to investigate the effect of ginseng on antioxidant enzyme levels in brain damage following experimental diffuse head trauma in rats. The neuroprotective effect of ginseng was also studied. In this study, rats were divided into four groups, and the rats in group 1 received no intervention. In group 2, the rats were administered 50 mg/kg ginseng, injected intraperitoneally at 1, 24 and 48 h, and the effect of ginseng on normal tissues was studied. No drugs were administered to the rats in group 3 who had previously experienced diffuse head trauma using Feeney's falling weight method. In group 4, rats underwent Feeney's falling weight method, leading to diffuse head trauma, and they were given 50 mg/kg ginseng intraperitoneally 1, 24 and 48 h after head trauma. Rats were killed 72 h after head trauma and their brain tissues extracted for histopathological and biochemical studies. Histopathological study of brain cross sections in the trauma group demonstrated neurons in the trauma region and surrounding area, which generally had a dark-colored eosinophilic cytoplasm and a pyknotic nucleus, while the nuclei of neurons were located peripherally. However, brain cross sections in group 4 from rats given ginseng after head trauma showed fewer neurons with eosinophilic cytoplasm, pyknotic and peripheral nuclei in the trauma region and surrounding area. No statistically significant difference in the tissue SOD level was observed; however, the GSH Px level in group 4 was significantly reduced compared to that in group 3. After affecting the GSH Px level and reducing histopathological scores, ginseng was found to display antioxidant and neuroprotective activity.en_US
dc.identifier.doi10.1007/s00701-013-1672-6
dc.identifier.endpage922en_US
dc.identifier.issn0001-6268
dc.identifier.issn0942-0940
dc.identifier.issue5en_US
dc.identifier.pmid23508485en_US
dc.identifier.scopus2-s2.0-84886541064en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage913en_US
dc.identifier.urihttps://doi.org/10.1007/s00701-013-1672-6
dc.identifier.urihttps://hdl.handle.net/11616/96251
dc.identifier.volume155en_US
dc.identifier.wosWOS:000317679800025en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofActa Neurochirurgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiffuse head traumaen_US
dc.subjectGinsengen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectSuperoxide dismutaseen_US
dc.titleStudy of the neuroprotective effect of ginseng on superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels in experimental diffuse head traumaen_US
dc.typeArticleen_US

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