Assocıatıons Between Vıtamın D Receptor Gene Polymorphısms and Carpal Tunnel Syndrome

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dc.contributor.authorYildiz, B.
dc.contributor.authorAlgul, F. E.
dc.contributor.authorYesilada, E.
dc.date.accessioned2026-04-04T13:30:51Z
dc.date.available2026-04-04T13:30:51Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground:Vitamin D deficiency is associated with Carpal tunnel syndrome (CTS), and Vitamin D supplementation may improve symptoms and electrophysiological findings in CTS patients. The biological effects of vitamin D may be modified by various genetic factors, including single nucleotide polymorphisms in the vitamin D receptor (VDR) gene.Aim:With this study, we aimed to show whether Taq I and Fok I polymorphisms of the VDR gene cause an increase in the occurrence and severity of carpal tunnel syndrome.Methods:100 CTS patients and 100 healthy controls were included in this study. The severity of CTS was determined by electromyography and the patients were divided into 3 groups: mild, moderate and severe CTS. The Fok I and Taq I genotypes of the participants were determined from the peripheral blood samples taken from all participants. Genotypes and allele frequencies were compared between patient and control groups.Results:VDR Fok I genotype distribution and allele frequency showed a significant relationship with the risk of developing CTS and its severity. Taq I, on the other hand, was not associated with the risk of developing CTS or its severity.Conclusion:VDR Fok I polymorphism increases the risk of developing CTS and the risk of severe CTS in the Turkish population. Further studies on this subject are needed to further understand the relationship between CTS and VDR polymorphisms and explain its mechanism.
dc.description.sponsorshipInonu University Scientific Research Projects Unit [TTU-2023-3256]
dc.description.sponsorshipThis study was supported by Inonu University Scientific Research Projects Unit (Project code: TTU-2023-3256).
dc.identifier.doi10.4103/njcp.njcp_774_24
dc.identifier.endpage720
dc.identifier.issn1119-3077
dc.identifier.issn2229-7731
dc.identifier.issue6
dc.identifier.pmid40556084
dc.identifier.scopus2-s2.0-105009256896
dc.identifier.scopusqualityQ2
dc.identifier.startpage716
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_774_24
dc.identifier.urihttps://hdl.handle.net/11616/108427
dc.identifier.volume28
dc.identifier.wosWOS:001515198700009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNigerian Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCarpal tunnel syndrome
dc.subjectFok I
dc.subjectTaq I
dc.subjectvitamin D
dc.subjectvitamin D receptor gene polymorphisms
dc.titleAssocıatıons Between Vıtamın D Receptor Gene Polymorphısms and Carpal Tunnel Syndrome
dc.typeArticle

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