Clinical significance of pulmonary function tests in patients with acute pancreatitis

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dc.authoridHacievliyagil, Suleyman Savas/0000-0002-2572-1870
dc.authoridKarincaoglu, Melih/0000-0002-9727-5128
dc.authorwosidHacievliyagil, Suleyman Savas/ABI-7307-2020
dc.contributor.authorAtes, F
dc.contributor.authorHacievliyagil, S
dc.contributor.authorKarincaoglu, M
dc.date.accessioned2024-08-04T20:15:12Z
dc.date.available2024-08-04T20:15:12Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate changes in pulmonary function tests (PFTs) in patients with acute pancreatitis (AP), to compare them with those changes in healthy controls, and to analyze the relationship between these parameters and computed tomography severity index (CTSI) and Ranson's criteria scores as markers of disease severity. This study included 40 patients with AP without a diagnosis of any pulmonary disease and 40 sex- and age-matched healthy controls. All participants were evaluated with simple PFTs and single-breath carbon monoxide (CO) diffusion tests. Patients with AP were also evaluated according to their CTSI and Ranson's criteria scores as markers of disease severity. The forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC, and peak expiratory flow, which determine lung capacity, were similar in the two groups. The forced expiratory volume during the middle half of the FVC (FEF25 - 75%), CO diffusing capacity (D-LCO), and ratio of D-LCO to alveolar ventilation (D-LCO/V-A), which determines alveolar membrane permeability, revealed a statistically significant decline in pulmonary gas exchange in patients with AP (P < 0.05). Correlation analysis showed that there is a significant negative relationship between CTSI and Ranson's criteria scores with FEF25 - 75%, D-LCO, and D-LCO/V-A (P < 0.05). We suggest that AP may cause impaired alveolar gas exchange without manifest pulmonary diseases. The effect of AP on FEF25 - 75%, D-LCO, and D-LCO/V-A appears to be dependent not only on the disease, but also on its severity. FEF25 - 75%, D-LCO, and D-LCO/V-A may give additional prognostic information in patients with AP in the initial evaluation.en_US
dc.identifier.doi10.1007/s10620-006-3074-6
dc.identifier.endpage10en_US
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.issue1en_US
dc.identifier.pmid16416201en_US
dc.identifier.scopus2-s2.0-30844466894en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1007/s10620-006-3074-6
dc.identifier.urihttps://hdl.handle.net/11616/94229
dc.identifier.volume51en_US
dc.identifier.wosWOS:000234602300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute pancreatitisen_US
dc.subjectpulmonary function testsen_US
dc.subjectcarbon monoxide diffusion testen_US
dc.subjectcomputed tomography severity indexen_US
dc.subjectRanson's criteriaen_US
dc.titleClinical significance of pulmonary function tests in patients with acute pancreatitisen_US
dc.typeArticleen_US

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