Physiological and pharmacological concentrations of melatonin protect against cisplatin-induced acute renal injury

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorParlakpinar, H
dc.contributor.authorSahna, E
dc.contributor.authorOzer, MK
dc.contributor.authorOzugurlu, F
dc.contributor.authorVardi, N
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:13:10Z
dc.date.available2024-08-04T20:13:10Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCisplatin [cis -diaminedichloroplatinum(II), CDDP] is a widely used antineoplastic drug. However, it has major side-effects such as acute tubular necrosis (ATN). There are a number of studies concerning the role of reactive oxygen radical species in the pathophysiology of CDDP-dependent ATN. Several antioxidant agents have been reported to prevent this side-effect but there is no study regarding the protective action of either physiological or pharmacological concentrations of melatonin. Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger and indirect antioxidant. We investigated the effects of melatonin on CDDP-induced changes of renal malondialdehyde (MDA), a lipid peroxidation product, and blood urea nitrogen (BUN) and serum creatine (Cr). The morphological changes in kidney were also examined using light microscopy. The rats were divided into two groups: pinealectomized (Px) and sham-operated (non-Px). Both CDDP and melatonin were administered to all groups. MDA levels were found to be higher in Px than non-Px animals. CDDP administration to Px or non-Px rats increased renal MDA levels and melatonin administration either before or after CDDP injection caused significant decreases in MDA in kidney compared with those in rats treated with CDDP alone. Serum levels of BUN and Cr did not change as a result of any treatment. Morphological tubule damage because of CDDP was more severe in the renal cortex than in the medulla. The damage to the kidney induced by CDDP was reversed by melatonin. The results show that pharmacological and physiological concentrations of melatonin reduce CDDP-induced renal injury.en_US
dc.identifier.doi10.1034/j.1600-079X.2002.02910.x
dc.identifier.endpage166en_US
dc.identifier.issn0742-3098
dc.identifier.issue3en_US
dc.identifier.pmid12220331en_US
dc.identifier.scopus2-s2.0-0036786265en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.1034/j.1600-079X.2002.02910.x
dc.identifier.urihttps://hdl.handle.net/11616/93439
dc.identifier.volume33en_US
dc.identifier.wosWOS:000177852400007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Munksgaarden_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcisplatinen_US
dc.subjectmalondialdehydeen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectraten_US
dc.subjectrenal injuryen_US
dc.titlePhysiological and pharmacological concentrations of melatonin protect against cisplatin-induced acute renal injuryen_US
dc.typeArticleen_US

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