Phytochemical compounds and antiradical, antimicrobial, and cytotoxic activities of the extracts from Hypericum scabrum L. Flowers

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dc.authoridKaygili, Omer/0000-0002-2321-1455
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridKaratepe, Mustafa/0000-0001-6358-5913
dc.authoridPARLAK, AKIF EVREN/0000-0002-2579-9985
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridTurkoglu, Semra/0000-0001-7682-0513
dc.authoridKESER, Serhat/0000-0002-9678-1053
dc.authorwosidKaygili, Omer/A-4801-2017
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidKaratepe, Mustafa/HII-5655-2022
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidPARLAK, AKIF EVREN/GNO-9528-2022
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidParlak, Akif Evren/V-8579-2018
dc.contributor.authorKeser, Serhat
dc.contributor.authorKeser, Fatma
dc.contributor.authorKaygili, Omer
dc.contributor.authorTekin, Suat
dc.contributor.authorDemir, Ersin
dc.contributor.authorTurkoglu, Ismail
dc.contributor.authorTurkoglu, Semra
dc.date.accessioned2024-08-04T20:45:33Z
dc.date.available2024-08-04T20:45:33Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHypericum scabrum L. has been widely used in traditional medicine for the treatment of many diseases just as the other Hypericum species. In the present study, the antiradical, antimicrobial and cytotoxic activities of water and ethanol extracts of H. scabrum flowers were investigated. Their phytochemical contents and composition were also determined. The water and ethanol extracts are better scavenged ABTS (97.89 and 98.99%) and OH radicals (96.36 and 97.33%); the water extract is better scavenged DPPH radicals (91.66%) than the standard antioxidant BHA (94.33, 85.19, 90.16%, respectively). Flowers of H. scabrum contain flavonoids, phenolic acids, vitamins and phytosterols, dominated by catechin, vanillic acid, vitamin K and ergosterol. The extracts exhibit a strong cytotoxic activity against MCF-7, HCT-116, and LNCaP cancer cell lines. It is found that their antimicrobial activities are higher than the standard antibiotics. These results indicate that H. scabrum flowers have potent antiradical, antimicrobial and cytotoxic activities.en_US
dc.identifier.doi10.1080/14786419.2018.1493735
dc.identifier.endpage719en_US
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.issue5en_US
dc.identifier.pmid30417678en_US
dc.identifier.scopus2-s2.0-85057314495en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage714en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2018.1493735
dc.identifier.urihttps://hdl.handle.net/11616/98549
dc.identifier.volume34en_US
dc.identifier.wosWOS:000517117400015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHen_US
dc.subjectscabrumen_US
dc.subjectantiradicalen_US
dc.subjectphytochemicalen_US
dc.subjectcytotoxicen_US
dc.subjectantimicrobialen_US
dc.titlePhytochemical compounds and antiradical, antimicrobial, and cytotoxic activities of the extracts from Hypericum scabrum L. Flowersen_US
dc.typeArticleen_US

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